(Q35005784)

5 August 2017

title

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis (English)

1 reference

5 August 2017

2

Jaroslaw Daniluk

1 reference

5 August 2017

Sebastian Gaiser

1

1 reference

5 August 2017

Yan Liu

3

1 reference

5 August 2017

Lilian Tsou

4

1 reference

5 August 2017

Jun Chu

5

1 reference

5 August 2017

Woojin Lee

6

1 reference

5 August 2017

Daniel S Longnecker

7

1 reference

5 August 2017

Craig D Logsdon

8

1 reference

5 August 2017

Baoan Ji

9

1 reference

5 August 2017

language of work or name

English

0 references

publication date

6 April 2011

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5 August 2017

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5 August 2017

volume

60

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5 August 2017

issue

10

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5 August 2017

page(s)

1379-1388

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Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death

5 August 2017

cites work

1 reference

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Ras activity levels control the development of pancreatic diseases.

8 July 2018

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Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation

8 July 2018

1 reference

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Robust acinar cell transgene expression of CreErT via BAC recombineering

8 July 2018

1 reference

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Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis

8 July 2018

1 reference

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Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Why does pancreatic overstimulation cause pancreatitis?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Clinical practice. Acute pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Expression of mutated cationic trypsinogen reduces cellular viability in AR4-2J cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Severe acute pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Alkylating DNA damage stimulates a regulated form of necrotic cell death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Rapid generation of inducible mouse mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Trypsinogen stabilization by mutation Arg117-->His: a unifying pathomechanism for hereditary pancreatitis?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Hereditary pancreatitis-associated mutation asn(21) --> ile stabilizes rat trypsinogen in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Progression of alcoholic acute to chronic pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Focal fatty replacement of the pancreas: usefulness of chemical shift MRI.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Cell death in pancreatitis: caspases protect from necrotizing pancreatitis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

The continuing challenge of early mortality in acute pancreatitis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Early NF-kappaB activation is associated with hormone-induced pancreatitis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304390

Mechanisms of intracellular zymogen activation

26 October 2018

1 reference

12 December 2020

NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response

1 reference

12 December 2020

Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis

1 reference

12 December 2020

Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitis

1 reference

12 December 2020

Subcellular kinetics of early trypsinogen activation in acute rodent pancreatitis

1 reference

12 December 2020

Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats

1 reference

12 December 2020

Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats

1 reference

12 December 2020

Identifiers

DOI

10.1136/GUT.2010.226175

1 reference

5 August 2017

1 reference

5 August 2017

1 reference