(Q35006087)

5 August 2017

title

U0126 protects cells against oxidative stress independent of its function as a MEK inhibitor (English)

1 reference

5 August 2017

1 reference

ChEBI release 2020-05-28

4

Bianxiao Cui

1 reference

5 August 2017

Qunxiang Ong

1

1 reference

5 August 2017

Shunling Guo

series ordinal

2

1 reference

5 August 2017

Kai Zhang

series ordinal

3

1 reference

5 August 2017

publication date

6 January 2015

1 reference

ACS Chemical Neuroscience

5 August 2017

published in

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5 August 2017

volume

6

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5 August 2017

issue

1

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5 August 2017

page(s)

130-137

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describes a project that uses

5 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4304487/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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8 July 2018

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Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth

8 July 2018

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8 July 2018

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MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling

8 July 2018

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Off-target effects of MEK inhibitors

8 July 2018

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Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells

8 July 2018

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The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2

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Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation

8 July 2018

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8 July 2018

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The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish

8 July 2018

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Light affects mitochondria to cause apoptosis to cultured cells: possible relevance to ganglion cell death in certain optic neuropathies

8 July 2018

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Inhibition of mitogen-activated protein kinase kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells

8 July 2018

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Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc.

8 July 2018

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Roles of Ras-Erk in apoptosis of PC12 cells induced by trophic factor withdrawal or oxidative stress

8 July 2018

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A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice.

8 July 2018

1 reference

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ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3.

8 July 2018

1 reference

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An investigation of the MEK/ERK inhibitor U0126 in acute myeloid leukemia

8 July 2018

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Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.

8 July 2018

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Mutations of the BRAF gene in human cancer

8 July 2018

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The catalytic pathway of horseradish peroxidase at high resolution

8 July 2018

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The Raf/MEK/ERK pathway: new concepts of activation.

8 July 2018

1 reference

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Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

Hydroxyl-radical production in physiological reactions. A novel function of peroxidase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

Chronic in vivo sodium azide infusion induces selective and stable inhibition of cytochrome c oxidase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

The kinetics and mechanism of iron (3) exchange between chelates and transferrin. I. The complexes of citrate and nitrilotriacetic acid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

H2O2 delivery to cells: steady-state versus bolus addition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

MEK-inhibitor U0126 in hyperglycaemic focal ischaemic brain injury in the rat.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

Blue light induces mitochondrial DNA damage and free radical production in epithelial cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

The centennial of the Fenton reaction.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4304487

26 October 2018

Identifiers

DOI

10.1021/CN500288N

1 reference

5 August 2017

1 reference

5 August 2017

1 reference