(Q35010692)

5 August 2017

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title

Pathogenesis, treatment, and prevention of pneumococcal pneumonia (English)

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5 August 2017

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1

Tom van der Poll

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5 August 2017

2

Steven M Opal

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5 August 2017

language of work or name

English

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publication date

1 October 2009

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5 August 2017

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5 August 2017

volume

374

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5 August 2017

issue

9700

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5 August 2017

page(s)

1543-1556

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A brief history of the pneumococcus in biomedical research: a panoply of scientific discovery.

5 August 2017

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Halting a pneumococcal pneumonia outbreak among United States Marine Corps trainees

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7 January 2021

Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children

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7 January 2021

Clonal Relationships between Invasive and Carriage Streptococcus pneumoniae and Serotype‐ and Clone‐Specific Differences in Invasive Disease Potential

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7 January 2021

Indirect effect of 7-valent pneumococcal conjugate vaccine on pneumococcal colonization among unvaccinated household members

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7 January 2021

International Circumpolar Surveillance System for invasive pneumococcal disease, 1999-2005

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7 January 2021

Use of proton pump inhibitors and the risk of community-acquired pneumonia: a population-based case-control study

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7 January 2021

Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia

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7 January 2021

CD14 Facilitates Invasive Respiratory Tract Infection byStreptococcus pneumoniae

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7 January 2021

Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

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7 January 2021

Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6.

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7 January 2021

Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease

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7 January 2021

Microarray analysis of pneumococcal gene expression during invasive disease

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7 January 2021

Nucleotide sequence changes between Streptococcus pneumoniae R6 and D39 strains determined by an oligonucleotide hybridization DNA sequencing technology.

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7 January 2021

Development of genomic array footprinting for identification of conditionally essential genes in Streptococcus pneumoniae

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7 January 2021

A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice

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7 January 2021

Genomic diversity between strains of the same serotype and multilocus sequence type among pneumococcal clinical isolates

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7 January 2021

The blp bacteriocins of Streptococcus pneumoniae mediate intraspecies competition both in vitro and in vivo.

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7 January 2021

Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis

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7 January 2021

Relationship between codon biased genes, microarray expression values and physiological characteristics of Streptococcus pneumoniae.

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7 January 2021

Rise and persistence of global M1T1 clone of Streptococcus pyogenes

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7 January 2021

Methicillin-ResistantS. aureusInfections among Patients in the Emergency Department

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https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Clostridium difficile--more difficult than ever

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7 January 2021

Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

The role of pneumolysin in pneumococcal pneumonia and meningitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae

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https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice

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7 January 2021

In vivo binding of complement regulator factor H by Streptococcus pneumoniae.

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7 January 2021

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions.

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7 January 2021

Pneumococcal virulence factors: structure and function

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7 January 2021

The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis.

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7 January 2021

Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae

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7 January 2021

The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence.

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7 January 2021

Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis

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7 January 2021

Pathogen recognition and innate immunity

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7 January 2021

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

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7 January 2021

Role of the property of C-reactive protein to activate the classical pathway of complement in protecting mice from pneumococcal infection

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7 January 2021

Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide

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7 January 2021

Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor

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7 January 2021

Improved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient mice

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7 January 2021

The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Lipoteichoic acid is important in innate immune responses to gram-positive bacteria.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease

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7 January 2021

TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae

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7 January 2021

Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection

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7 January 2021

Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

IL-18 improves the early antimicrobial host response to pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Pyogenic bacterial infections in humans with MyD88 deficiency

1 reference

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7 January 2021

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

1 reference

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7 January 2021

Intracellular trafficking and killing of Streptococcus pneumoniae by human alveolar macrophages are influenced by opsonins

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

1 reference

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7 January 2021

The inflammasome: first line of the immune response to cell stress

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7 January 2021

Innate immunity in the lung: how epithelial cells fight against respiratory pathogens

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https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia

1 reference

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7 January 2021

The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs

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7 January 2021

CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia.

1 reference

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7 January 2021

Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia

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https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Differential contribution of bacterial N-formyl-methionyl-leucyl- phenylalanine and host-derived CXC chemokines to neutrophil infiltration into pulmonary alveoli during murine pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Role of chemokines and formyl peptides in pneumococcal pneumonia-induced monocyte/macrophage recruitment

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

The importance of neutrophils in resistance to pneumococcal pneumonia in adult and neonatal mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Host cellular immune response to pneumococcal lung infection in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Pulmonary dendritic cells and alveolar macrophages are regulated by gammadelta T cells during the resolution of S. pneumoniae-induced inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Potential hazards of combination immunotherapy in the treatment of experimental septic shock

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

The role of interferon-gamma in murine pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Nuclear factor-kappaB activation in mouse lung lavage cells in response to Streptococcus pneumoniae pulmonary infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

IkappaB genetic polymorphisms and invasive pneumococcal disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Coagulation abnormalities in critically ill patients

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats*

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Patterns of resolution of chest radiograph abnormalities in adults hospitalized with severe community-acquired pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Guidelines for the management of adult lower respiratory tract infections

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https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Quantitative PCR assay using sputum samples for rapid diagnosis of pneumococcal pneumonia in adult emergency department patients

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https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Toward a quantitative DNA-based definition of pneumococcal pneumonia: a comparison of Streptococcus pneumoniae target genes, with special reference to the Spn9802 fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome

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7 January 2021

The effect of cephalosporin resistance on mortality in adult patients with nonmeningeal systemic pneumococcal infections

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Failure of Macrolide Antibiotic Treatment in Patients with Bacteremia Due to Erythromycin‐Resistant Streptococcus pneumoniae

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Combination Antibiotic Therapy Lowers Mortality among Severely Ill Patients with Pneumococcal Bacteremia

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https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Changes in invasive Pneumococcal disease among HIV-infected adults living in the era of childhood pneumococcal immunization

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Pneumococcal vaccine--direct and indirect ("herd") effects

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Changing characteristics of invasive pneumococcal disease in Metropolitan Atlanta, Georgia, after introduction of a 7-valent pneumococcal conjugate vaccine

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Increase in the prevalence of the newly discovered pneumococcal serotype 6C in the nasopharynx after introduction of pneumococcal conjugate vaccine

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Pneumococcal mastoiditis in children and the emergence of multidrug-resistant serotype 19A isolates

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Bacteremic pneumococcal pneumonia in one American City: a 20-year longitudinal study, 1978-1997.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

Vaccine escape recombinants emerge after pneumococcal vaccination in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2809%2961114-4

7 January 2021

10.1016/S0140-6736(09)61114-4

Identifiers

DOI

1 reference

5 August 2017

1 reference