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Genetic approaches to understanding human obesity.
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1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
review article
1 reference
stated in
Europe PubMed Central
title
Genetic approaches to understanding human obesity
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
main subject
obesity
0 references
author
Sadaf Farooqi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
author name string
Shwetha Ramachandrappa
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
language of work or name
English
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publication date
1 June 2011
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stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
published in
Journal of Clinical Investigation
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stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
volume
121
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
issue
6
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
page(s)
2080-2086
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
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Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease
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Leptin regulates striatal regions and human eating behavior
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8 July 2018
Variation in FTO contributes to childhood obesity and severe adult obesity
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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
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Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
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Leptin regulation of the mesoaccumbens dopamine pathway.
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8 July 2018
Leptin receptor signaling in midbrain dopamine neurons regulates feeding
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Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
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8 July 2018
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight
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8 July 2018
Anatomy and regulation of the central melanocortin system
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8 July 2018
Leptin in immunology
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8 July 2018
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
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8 July 2018
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy
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8 July 2018
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
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Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome
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The role of depot fat in the hypothalamic control of food intake in the rat.
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8 July 2018
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
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8 July 2018
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.
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Gs(alpha) mutations and imprinting defects in human disease
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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
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8 July 2018
Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
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8 July 2018
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
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8 July 2018
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
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8 July 2018
Central nervous system control of food intake
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
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8 July 2018
Genetics of body-weight regulation
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PubMed Central
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8 July 2018
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
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8 July 2018
Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin,
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8 July 2018
Effects of recombinant leptin therapy in a child with congenital leptin deficiency.
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8 July 2018
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
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8 July 2018
Distributions of leptin receptor mRNA isoforms in the rat brain
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Congenital leptin deficiency is associated with severe early-onset obesity in humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Overfeeding in identical twins: 5-year postoverfeeding results
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Role of leptin in the neuroendocrine response to fasting
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Positional cloning of the mouse obese gene and its human homologue
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Effects of parabiosis of normal with genetically diabetic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Genetics of obesity in adult adoptees and their biological siblings
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
8 July 2018
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Modulation of blood pressure by central melanocortinergic pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Cilia: tails of the unexpected
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Studies of the SIM1 gene in relation to human obesity and obesity-related traits.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
A role for beta-melanocyte-stimulating hormone in human body-weight regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
The effects of lesions in the hypothalamus in parabiotic rats.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Elevated plasma ghrelin levels in Prader–Willi syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
A leptin missense mutation associated with hypogonadism and morbid obesity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
A twin study of human obesity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Prevalence and functionality of paucimorphic and privateMC4Rmutations in a large, unselected European British population, scanned by meltMADGE
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
25 October 2018
Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
9 December 2018
Heterozygosity for aPOMC-Null Mutation and Increased Obesity Risk in Humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
9 December 2018
The Body-Mass Index of Twins Who Have Been Reared Apart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104766
retrieved
9 December 2018
The heritability of body mass index among an international sample of monozygotic twins reared apart
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21633175
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Obesity in the new millennium
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21633175
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The severely obese patient--a genetic work-up
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21633175
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The response to long-term overfeeding in identical twins
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21633175
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Abnormalities of the somatotrophic axis in the obese agouti mouse
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21633175
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1172/JCI46044
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
PMCID
3104766
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
PubMed ID
21633175
1 reference
stated in
Europe PubMed Central
PMCID
3104766
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21633175%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
ResearchGate publication ID
51184466
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