(Q35018619)

5 August 2017

title

S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase (English)

1 reference

5 August 2017

Matthew Brecher

3

0 references

Nilesh Banavali

object named as

Nilesh Banavali

4

0 references

Hongmin Li

object named as

Hongmin Li

11

0 references

Laura D Kramer

9

object named as

Laura D Kramer

1 reference

5 August 2017

Hui Chen

1

1 reference

5 August 2017

Bing Zhou

2

1 reference

5 August 2017

Susan A Jones

5

1 reference

5 August 2017

Zhong Li

6

1 reference

5 August 2017

Jing Zhang

7

1 reference

5 August 2017

Dilip Nag

8

1 reference

5 August 2017

Arun K Ghosh

10

1 reference

5 August 2017

language of work or name

English

0 references

publication date

9 October 2013

1 reference

5 August 2017

1 reference

5 August 2017

volume

8

1 reference

5 August 2017

issue

10

1 reference

5 August 2017

page(s)

e76900

1 reference

Creative Commons Attribution 4.0 International

5 August 2017

copyright license

start time

9 October 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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1 reference

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Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation

8 July 2018

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Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs

8 July 2018

1 reference

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Automation of the CHARMM General Force Field (CGenFF) I: bond perception and atom typing.

8 July 2018

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Automation of the CHARMM General Force Field (CGenFF) II: assignment of bonded parameters and partial atomic charges.

8 July 2018

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Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2

8 July 2018

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Flaviviruses and flavivirus vaccines

8 July 2018

1 reference

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2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase

8 July 2018

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Encephalitis caused by flaviviruses

8 July 2018

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Flavivirus RNA cap methyltransferase: structure, function, and inhibition

8 July 2018

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Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

8 July 2018

1 reference

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Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid

8 July 2018

1 reference

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Structure and functionality in flavivirus NS-proteins: perspectives for drug design

8 July 2018

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Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n).

8 July 2018

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CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

8 July 2018

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Identification and characterization of inhibitors of West Nile virus

8 July 2018

1 reference

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Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

8 July 2018

1 reference

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CHARMM: the biomolecular simulation program

8 July 2018

1 reference

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Analysis of Flavivirus NS5 Methyltransferase Cap Binding

8 July 2018

1 reference

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A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

8 July 2018

1 reference

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Molecular targets for flavivirus drug discovery

8 July 2018

1 reference

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Phosphorylation of yellow fever virus NS5 alters methyltransferase activity

8 July 2018

1 reference

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Flavivirus methyltransferase: a novel antiviral target

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

8 July 2018

1 reference

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Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

8 July 2018

1 reference

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Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Structure and Function of Flavivirus NS5 Methyltransferase

8 July 2018

1 reference

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West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

8 July 2018

1 reference

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Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

8 July 2018

1 reference

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An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: correlations with diet

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

trans-Complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

A mutational analysis of binding interactions in an antigen-antibody protein-protein complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosylhomocysteine.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0076900

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0076900

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0076900

Use of Oligodeoxyribonucleotides with Conformationally Constrained Abasic Sugar Targets To Probe the Mechanism of Base Flipping byHhaI DNA (Cytosine C5)-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0076900

Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3793912

Studies of metabolic changes in cell cultures infected with four serotypes of dengue fever viruses by frequency-pulsed electron-capture gas-liquid chromatography

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24130807

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0076900

1 reference

release_qxkutzvem5gnnpxcfgbvvntrcu

5 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qxkutzvem5gnnpxcfgbvvntrcu

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3793912

1 reference

5 August 2017

1 reference