(Q35019411)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

0 references

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

author name string

Sheel C Dodani

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Scot C Leary

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Dennis R Winge

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Christopher J Chang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

language of work or name

English

0 references

publication date

12 May 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

number of pages

11

1 reference

Journal of the American Chemical Society

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

volume

133

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

issue

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

page(s)

8606-8616

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

31 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3106114/fullTextXML

inferred from PubMed Central ID database lookup

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8 July 2018

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8 July 2018

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8 July 2018

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Application of metal coordination chemistry to explore and manipulate cell biology

8 July 2018

1 reference

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Targeting mitochondria with organelle-specific compounds: strategies and applications

8 July 2018

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8 July 2018

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8 July 2018

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Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis

8 July 2018

1 reference

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Preparation and use of Coppersensor-1, a synthetic fluorophore for live-cell copper imaging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Metal Ion availability in mitochondria.

8 July 2018

1 reference

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The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis

8 July 2018

1 reference

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Human Sco1 functional studies and pathological implications of the P174L mutant

8 July 2018

1 reference

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A smart magnetic resonance contrast agent for selective copper sensing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Between a rock and a hard place: trace element nutrition in Chlamydomonas

8 July 2018

1 reference

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p53 regulates mitochondrial respiration

8 July 2018

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Copper trafficking to the mitochondrion and assembly of copper metalloenzymes

8 July 2018

1 reference

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The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.

8 July 2018

1 reference

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A selective turn-on fluorescent sensor for imaging copper in living cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Human Sco1 and Sco2 function as copper-binding proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase "assembly" protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Human recombinant mutated forms of the mitochondrial COX assembly Sco2 protein differ from wild-type in physical state and copper binding capacity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Copper chaperones for cytochrome c oxidase and human disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Copper supplementation restores cytochrome c oxidase activity in cultured cells from patients with SCO2 mutations

8 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

8 July 2018

https://pubmed.ncbi.nlm.nih.gov/21563821

12 December 2020

inferred from PubMed ID database lookup

Cytochrome c oxidase deficiency due to mutations in SCO2, encoding a mitochondrial copper-binding protein, is rescued by copper in human myoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Biochemical characterization of the human copper transporter Ctr1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Homozygosity (E140K) in SCO2 causes delayed infantile onset of cardiomyopathy and neuropathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Metallochaperones, an intracellular shuttle service for metal ions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Structure and chemistry of the copper chaperone proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Molecular mechanisms of copper homeostasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Localization of mitochondria in living cells with rhodamine 123

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Mitochondrial Membrane Potential in Living Cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Development of highly sensitive fluorescent probes for detection of intracellular copper(I) in living systems

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Multiple triphenylphosphonium cations shuttle a hydrophilic peptide into mitochondria.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Development of mitochondria-targeted derivatives of resveratrol

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

The functions of Sco proteins from genome-based analysis.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

A hemizygous SCO2 mutation in an early onset rapidly progressive, fatal cardiomyopathy

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106114

Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21563821

12 December 2020

inferred from PubMed ID database lookup

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21563821

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/JA2004158

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21563821%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference