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Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases

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scholarly article

1 reference

Europe PubMed Central

5 August 2017

1 reference

Europe PubMed Central

Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases (English)

1 reference

Europe PubMed Central

5 August 2017

0 references

author name string

George M O'Keefe

1

1 reference

Europe PubMed Central

5 August 2017

Vince T Nguyen

2

1 reference

Europe PubMed Central

5 August 2017

Etty N Benveniste

3

1 reference

Europe PubMed Central

5 August 2017

publication date

1 December 2002

1 reference

Europe PubMed Central

5 August 2017

Journal of NeuroVirology

1 reference

Europe PubMed Central

5 August 2017

8

1 reference

Europe PubMed Central

5 August 2017

496-512

1 reference

Europe PubMed Central

5 August 2017

6

1 reference

Europe PubMed Central

5 August 2017

https://scigraph.springernature.com/pub.10.1080/13550280290100941

0 references

T cell interaction with ICAM-1-deficient endothelium in vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquisition of lymphokine-producing phenotype by CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB regulates MHC class II expression in a CIITA-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune regulation by CD40 and its ligand GP39.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of T cell inactivation by CTLA-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma regulation of class II transactivator promoter IV in macrophages and microglia: involvement of the suppressors of cytokine signaling-1 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mature microglia resemble immature antigen-presenting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunological synapse: a molecular machine controlling T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-lymphocyte entry into the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of action of interferon-beta in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of class II MHC expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative regulation of cytokine signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune regulation and CNS autoimmune disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional CD40 ligand is expressed by T cells in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40-CD40 ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class II transactivator: is it a master switch for MHC class II gene expression?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-immune connection: immuno-regulatory properties of CNS-resident cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CTLA-4: a negative regulator of autoimmune disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of MHC class II expression in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 is expressed and functional on neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the CCAAT-binding protein CBF/NF-Y in transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MHC class II restricted antigen presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines in inflammatory brain lesions: helpful and harmful

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune function of microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-gamma and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From marrow to brain: expression of neuronal phenotypes in adult mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of CD40 on B cells, dendritic cells and other cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CD40/CD154 receptor/ligand dyad

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and function of a new STAT-induced STAT inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central nervous system expression of IL-10 inhibits autoimmune encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding the mechanisms of sustained signaling and T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-2/IL-2 receptor system: a current overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD28/B7 system of T cell costimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common set of factors control the expression of the MHC class II, invariant chain, and HLA-DM genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balancing function vs. self defense: the CNS as an active regulator of immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New perspectives of CD28-B7-mediated T cell costimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models of T cell anergy: is there a common molecular mechanism?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Th1 and Th2 cells in neurologic disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a promoter element that regulates tissue-specific expression of the human CD80 (B7.1) gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T suppressor lymphocytes inhibit NF-kappa B-mediated transcription of CD86 gene in APC

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of and functional antigen presentation by central nervous system mononuclear cells from mice infected with Theiler's murine encephalomyelitis virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of MHC class II genes: lessons from a disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The class II transactivator CIITA is a transcriptional integrator

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory cytokines in the brain: does the CNS shape immune responses?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The central nervous system environment controls effector CD4+ T cell cytokine profile in experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40-CD40L interactions induce chemokine expression by human microglia: implications for human immunodeficiency virus encephalitis and multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of expression of the ligand for CD40 on T helper lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NF-?B activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of MHC class II deficiency and transcriptional control of MHC class II gene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative control of MHC class II expression by the transactivator CIITA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation and function of Fas expression on glial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death during autoimmune demyelination: effector but not target cells are eliminated by apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Th1/Th2 paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF-beta, IL-4, IL-13 and IL-10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma regulation of the type IV class II transactivator promoter in astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune responses in MHC class II-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class II MHC genes: a model gene regulatory system with great biologic consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: a sensor for pathological events in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 associates with the MHC class II molecules on human B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Making the T cell receptor go the distance: a topological view of T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationship

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional segregation of supramolecular activation clusters in T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia induce CD4 T lymphocyte final effector function and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic models for CNS inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 ligand inhibits Fas/CD95-mediated apoptosis of human blood-derived dendritic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-beta1 (TGF-beta1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40-mediated activation of T cells accelerates, but is not required for, encephalitogenic potential of myelin basic protein-recognizing T cells in a model of progressive experimental autoimmune encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and functional characterization of the 5'-regulatory region of the human CD86 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12476345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1080/13550280290100941

1 reference

Europe PubMed Central

5 August 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

5 August 2017

ResearchGate publication ID

0 references

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