(Q35023368)

English

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

based on heuristic

inferred from title

object named as

Leishmania

1 reference

based on heuristic

inferred from title

José María Pérez-Victoria

object named as

José M Pérez-Victoria

1

0 references

Francisco Gamarro

object named as

Francisco Gamarro

12

0 references

Maria Paola Costi

1 reference

ORCID Public Data File 2021

Attilio Di Pietro

10

object named as

Attilio Di Pietro

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Fernando Cortés-Selva

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Adriana Parodi-Talice

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Boris I Bavchvarov

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

F Javier Pérez-Victoria

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Francisco Muñoz-Martínez

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Mathias Maitrejean

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

M Paola Costi

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Denis Barron

9

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Santiago Castanys

11

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

0 references

publication date

1 September 2006

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Europe PubMed Central

PubMed publication ID

5 August 2017

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

50

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

3102-3110

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Mechanisms of drug action and drug resistance in Leishmania as basis for therapeutic target identification and design of antileishmanial modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Oral miltefosine for Indian visceral leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

ABC transporters in the protozoan parasite Leishmania.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

A policy for leishmaniasis with respect to the prevention and control of drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Reversal of chloroquine resistance in Plasmodium falciparum using combinations of chemosensitizers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Multiple recognition of various amphiphilic molecules by the multidrug resistance P-glycoprotein: molecular mechanisms and pharmacological consequences coming from functional interactions between various drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Plasmodium and Leishmania: the role of mdr genes in mediating drug resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Crystal structure of the Src family tyrosine kinase Hck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Apical membrane aminopeptidase appears at site of cell-cell contact in cultured kidney epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Breast tumor cell lines from pleural effusions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

A human cell line from a pleural effusion derived from a breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Pharmacology of drugs that alter multidrug resistance in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

ABC Transporters: From Microorganisms to Man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

8 July 2018

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

25 October 2018

Multiple flavonoid-binding sites within multidrug resistance protein MRP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

25 October 2018

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

25 October 2018

The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

25 October 2018

Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

25 October 2018

Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

25 October 2018

Saturation reversal of the multidrug pump using many reversers in low-dose combinations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1563564

25 October 2018

New Natural Sesquiterpenes as Modulators of Daunomycin Resistance in a Multidrug-ResistantLeishmaniatropicaLine‖,⊥

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1 ) expression caused by arsenite

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant N-terminal nucleotide-binding domain from mouse P-glycoprotein. Overexpression, purification, and role of cysteine 430

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of gastric H+, K(+)-ATPase by flavonoids: a structure-activity study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16940108

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00423-06

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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