(Q35028032)

English

Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.

scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

Europe PubMed Central

Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses. (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

toll-like receptor

0 references

inflammasome complex

1 reference

based on heuristic

inferred from title

author name string

Man Yu

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Stewart J Levine

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

publication date

3 April 2011

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Cytokine and Growth Factor Reviews

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

22

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

63-72

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Immunodeficiency and genetic defects of pattern-recognition receptors

1 reference

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Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulo

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Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways

1 reference

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ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

1 reference

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Retinoic acid-inducible gene-I-like receptors

1 reference

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Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding

1 reference

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Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1.

1 reference

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Central roles of NLRs and inflammasomes in viral infection

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Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus

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Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.

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Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis.

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Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

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Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-alpha and IFN-gamma dependent manners

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Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome

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TLR stimulation of prostate tumor cells induces chemokine-mediated recruitment of specific immune cell types.

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1 reference

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Influenza virus activates inflammasomes via its intracellular M2 ion channel

1 reference

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Anti-inflammatory Agents: Present and Future

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The inflammasomes

1 reference

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Primary immunodeficiencies of protective immunity to primary infections

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IL-1 pathways in inflammation and human diseases

1 reference

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TRAF5 is a downstream target of MAVS in antiviral innate immune signaling

1 reference

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RIG-I detects viral genomic RNA during negative-strand RNA virus infection

1 reference

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LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

1 reference

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1 reference

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Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

1 reference

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Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells

1 reference

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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

1 reference

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Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells

1 reference

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PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

1 reference

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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors

1 reference

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Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

1 reference

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TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination

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Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

1 reference

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

1 reference

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5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

1 reference

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1 reference

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Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.

1 reference

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Anakinra for rheumatoid arthritis: a systematic review

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The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

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The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

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RNA recognition and signal transduction by RIG-I-like receptors

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Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

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5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

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TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

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Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

1 reference

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

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Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

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NLRX1 is a regulator of mitochondrial antiviral immunity

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Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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RIP1, a kinase on the crossroads of a cell's decision to live or die

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Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

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NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction

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Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

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Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors

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TLR3 can directly trigger apoptosis in human cancer cells.

1 reference

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Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

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Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

1 reference

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A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

1 reference

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

1 reference

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TLR ignores methylated RNA?

1 reference

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8 July 2018

Cell type-specific involvement of RIG-I in antiviral response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

Transcriptional signaling by double-stranded RNA: role of TLR3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

Toll-like receptor control of the adaptive immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

Toll-like receptor signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

New drugs for rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

mRNA is an endogenous ligand for Toll-like receptor 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

Subcellular localization of Toll-like receptor 3 in human dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

8 July 2018

TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

TLR3 agonists as immunotherapeutic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

RIGorous detection: exposing virus through RNA sensing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

A nonself RNA pattern: tri-p to panhandle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Fighting the flu with inflammasome signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Double-stranded RNA-mediated TLR3 activation is enhanced by CD14.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

25 October 2018

A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109132

9 December 2018

Virology. Sensing viral RNA amid your own

1 reference

https://pubmed.ncbi.nlm.nih.gov/21466970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21466970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CYTOGFR.2011.02.001

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

0 references

Sitelinks

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