(Q35029184)

5 August 2017

title

Improving gene silencing of siRNAs via tricyclo-DNA modification (English)

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5 August 2017

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Damian Ittig

1

1 reference

5 August 2017

Samuel Luisier

2

1 reference

5 August 2017

Jan Weiler

3

1 reference

5 August 2017

Daniel Schümperli

4

1 reference

5 August 2017

Christian J Leumann

5

1 reference

5 August 2017

publication date

1 July 2010

1 reference

Artificial DNA, PNA & XNA

5 August 2017

published in

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5 August 2017

volume

1

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5 August 2017

issue

1

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5 August 2017

page(s)

9-16

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

RNA major groove modifications improve siRNA stability and biological activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Structure of the guide-strand-containing argonaute silencing complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Chemically modified siRNA: tools and applications.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Comparative studies of tricyclo-DNA- and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Chemical modification: the key to clinical application of RNA interference?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Study of modification pattern-RNAi activity relationships by using siRNAs modified with 4'-thioribonucleosides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Improved silencing properties using small internally segmented interfering RNAs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Inhibition of MDR1 expression with altritol-modified siRNAs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Illuminating the silence: understanding the structure and function of small RNAs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

RNAi therapeutics: a potential new class of pharmaceutical drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

RNAi: the nuts and bolts of the RISC machine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

RNA interference using boranophosphate siRNAs: structure-activity relationships

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Functional siRNAs and miRNAs Exhibit Strand Bias

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Asymmetry in the assembly of the RNAi enzyme complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

siRNA function in RNAi: a chemical modification analysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Antisense properties of tricyclo-DNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109438

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

8 July 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

Steric effects in RNA interference: probing the influence of nucleobase size and shape.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

Fully 2'-deoxy-2'-fluoro substituted nucleic acids induce RNA interference in mammalian cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

Watson-Crick base-pairing properties of tricyclo-DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

RNAi in human cells: basic structural and functional features of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

Structural Characterization and Biological Evaluation of Small Interfering RNAs Containing Cyclohexenyl Nucleosides

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FADNA.1.1.11385

21 January 2018

Identifiers

DOI

10.4161/ADNA.1.1.11385

1 reference

5 August 2017

1 reference

5 August 2017

1 reference