(Q36654918)

15 August 2017

1 reference

title

RNAi therapeutics: a potential new class of pharmaceutical drugs (English)

1 reference

15 August 2017

Victor E. Koteliansky

series ordinal

3

object named as

Victor Koteliansky

1 reference

15 August 2017

David Bumcrot

1

1 reference

15 August 2017

Muthiah Manoharan

series ordinal

2

1 reference

15 August 2017

Dinah W Y Sah

series ordinal

4

1 reference

15 August 2017

1 December 2006

1 reference

15 August 2017

Nature Chemical Biology

1 reference

15 August 2017

2

1 reference

15 August 2017

711-719

1 reference

15 August 2017

12

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio839

15 August 2017

0 references

cites work

Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide

1 reference

12 December 2020

Synthesis and physical and physiological properties of 4'-thioRNA: application to post-modification of RNA aptamer toward NF-kappaB

1 reference

12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

12 December 2020

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

1 reference

12 December 2020

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

1 reference

12 December 2020

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

1 reference

12 December 2020

RNA interference against Hec1 inhibits tumor growth in vivo

1 reference

12 December 2020

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

1 reference

12 December 2020

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

1 reference

12 December 2020

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

12 December 2020

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

1 reference

12 December 2020

Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.

1 reference

12 December 2020

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

1 reference

12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

1 reference

12 December 2020

Mechanistic insights aid computational short interfering RNA design.

1 reference

12 December 2020

Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.

1 reference

12 December 2020

A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

1 reference

12 December 2020

RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis.

1 reference

12 December 2020

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

1 reference

12 December 2020

Rational siRNA design for RNA interference

1 reference

12 December 2020

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

1 reference

12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

12 December 2020

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

1 reference

12 December 2020

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

1 reference

12 December 2020

siRNA relieves chronic neuropathic pain

1 reference

12 December 2020

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

1 reference

12 December 2020

A Toll-like receptor recognizes bacterial DNA

1 reference

12 December 2020

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

1 reference

12 December 2020

Expression profiling reveals off-target gene regulation by RNAi

1 reference

12 December 2020

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

1 reference

12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

12 December 2020

siRNA Selection Server: an automated siRNA oligonucleotide prediction server

1 reference

12 December 2020

The silent treatment: siRNAs as small molecule drugs

1 reference

12 December 2020

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

1 reference

12 December 2020

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

1 reference

12 December 2020

Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity

1 reference

12 December 2020

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

1 reference

12 December 2020

Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo

1 reference

12 December 2020

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

1 reference

12 December 2020

High potency silencing by single-stranded boranophosphate siRNA.

1 reference

12 December 2020

Engineering mucosal RNA interference in vivo

1 reference

12 December 2020

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

1 reference

12 December 2020

RNA interference by 2',5'-linked nucleic acid duplexes in mammalian cells

1 reference

12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

1 reference

12 December 2020

Induction of the interferon response by siRNA is cell type- and duplex length-dependent

1 reference

12 December 2020

Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

1 reference

12 December 2020

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

1 reference

12 December 2020

RNAi-mediated gene silencing in non-human primates.

1 reference

12 December 2020

Characterization and modulation of immune stimulation by modified oligonucleotides

1 reference

12 December 2020

Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma

1 reference

12 December 2020

RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo

1 reference

12 December 2020

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

1 reference

12 December 2020

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

1 reference

12 December 2020

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

1 reference

12 December 2020

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

1 reference

12 December 2020

RNA interference using boranophosphate siRNAs: structure-activity relationships

1 reference

12 December 2020

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

12 December 2020

Functional siRNAs and miRNAs Exhibit Strand Bias

1 reference

12 December 2020

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

1 reference

12 December 2020

Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference

1 reference

12 December 2020

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

1 reference

12 December 2020

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

12 December 2020

The prospect of silencing disease using RNA interference

1 reference

12 December 2020

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

1 reference

12 December 2020

Chemical modification of siRNAs to improve serum stability without loss of efficacy.

1 reference

12 December 2020

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

1 reference

12 December 2020

Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine

1 reference

12 December 2020

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

1 reference

12 December 2020

Therapeutic potential of RNA interference against cancer

1 reference

12 December 2020

Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs

1 reference

12 December 2020

Designing siRNA that distinguish between genes that differ by a single nucleotide

1 reference

12 December 2020

RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts.

1 reference

12 December 2020

A computational study of off-target effects of RNA interference

1 reference

12 December 2020

Different delivery methods-different expression profiles

1 reference

12 December 2020

Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain

1 reference

12 December 2020

Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.

1 reference

12 December 2020

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

1 reference

12 December 2020

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

1 reference

12 December 2020

The roles of hydrogen bonding and sterics in RNA interference

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO839

1 reference

release_lvaclro2gvhcnnwxfn3y3wlgp4

15 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lvaclro2gvhcnnwxfn3y3wlgp4

24 November 2022

mapped directly with Wikidata item

1 reference