(Q35032999)

English

Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays

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scholarly article

1 reference

Europe PubMed Central

5 August 2017

Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays (English)

1 reference

Europe PubMed Central

5 August 2017

author name string

M Taningher

1

1 reference

Europe PubMed Central

5 August 2017

G Saccomanno

2

1 reference

Europe PubMed Central

5 August 2017

L Santi

3

1 reference

Europe PubMed Central

5 August 2017

S Grilli

4

1 reference

Europe PubMed Central

5 August 2017

S Parodi

5

1 reference

Europe PubMed Central

5 August 2017

publication date

1 March 1990

1 reference

Europe PubMed Central

5 August 2017

number of pages

10

1 reference

based on heuristic

inferred from page(s)

Environmental Health Perspectives

1 reference

Europe PubMed Central

5 August 2017

84

1 reference

Europe PubMed Central

5 August 2017

183-192

1 reference

Europe PubMed Central

5 August 2017

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

A benzo[alpha]pyrene-7,8-dihydrodiol-9,10-epoxide is the major metabolite involved in the binding of benzo[alpha]pyrene to DNA in isolated viable rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome P-450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Evaluation of metabolic activation of 7,12-dimethylbenz(a)anthracene in vitro by aroclor 1254-induced rat liver S-9 fraction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Quantitative predictivity of the transformation in vitro assay compared with the Ames test.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

A carcinogenic potency database of the standardized results of animal bioassays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Comparative kinetic studies on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with rat and hamster livers in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Glutathione-mediated binding of dibromoalkanes to DNA: specificity of rat glutathione-S-transferases and dibromoalkane structure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methylthymidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Effect of microsomal activation on interaction between isophosphamide and DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

In vivo and in vitro binding of ethionine with nucleic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

The mofidication of nucleosides and nucleotides. IV. The reaction of semicarbazide with nucleic acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Binding of metabolites of cyclophosphamide to DNA in a rat liver microsomal system and in vivo in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

The activation and DNA binding of 7-methylbenz[c]-acridine catalysed by mouse liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Assembly and preliminary analysis of a genotoxicity data base for predicting carcinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Evaluation of the DNA-repair host-mediated assay. I. Induction of repairable DNA damage in E. coli cells recovered from liver, spleen, lungs, kidneys, and the blood stream of mice treated with methylating carcinogens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Quantitative predictivity of carcinogenicity of the autoradiographic repair test (primary hepatocyte cultures) for a group of 80 chemicals belonging to different chemical classes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Utilization of the quantitative component of positive and negative results of short-term tests

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Short-term testing--are we looking at wrong endpoints?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Short-term tests of genotoxicity for 1,1,1-trichloroethane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

1,1,2-Trichloroethane: evidence of genotoxicity from short-term tests.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Binding of diethylstilboestrol to deoxyribonucleic acid by rat liver microsomal fractions in vitro and in mouse foetal cells in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Covalent binding of the carcinogen trichloroethylene to hepatic microsomal proteins and to exogenous DNA in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Comparative binding studies on 1,1'-ethylene-bis(1-nitrosourea) and some 1-alkyl-1-nitrosoureas with nucleic acids and proteins in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Similarity of nuclear and microsomal cytochromes P-450 in the in vitro activation of aflatoxin B1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Role of dimethylnitrosamine-demethylase in the metabolic activation of dimethylnitrosamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Comparison of aflatoxin B1 and aflatoxin G1 binding to cellular macromolecules in vitro, in vivo and after peracid oxidation; characterisation of the major nucleic acid adducts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Comparative studies on the covalent binding of the carcinogen benzo(a)pyrene to DNA in various model systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

The detection of various nitrosamines in the hepatocyte primary culture/DNA repair test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Interaction of potential metabolites of the carcinogen ethylene dibromide with protein and DNA in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Binding of Carcinogenic Halogenated Hydrocarbons to Cell Macromolecules2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

The metabolic activation of benzo(a)pyrene and 9-hydroxybenzo (a) pyrene by liver microsomal fractions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

The relationship between metabolism, DNA binding, and carcinogenicity of 15,16-dihydro-11-methylcyclopenta(alpha)phenanthren-17-one in the presence of a microsomal enzyme inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3′-5′)thymidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Specificity of different classes of ethylating agents toward various sites of HeLa cell DNA in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Factors influencing the microsome- and mitochondria-catalyzed in vitro binding of diethylnitrosamine and N-nitrosopiperidine to deoxyribonucleic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

8 July 2018

Binding of quinoline to nucleic acid in a subcellular microsomal system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

25 October 2018

Inactivation of DNA-binding metabolites of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by glutathione and glutathione S-transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

25 October 2018

Effect of butylated hydroxyanisole on the metabolism of benzo[a]-pyrene and the binding of metabolites to DNA, in vitro and in vivo, in the forestomach, lung, and liver of mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

25 October 2018

In vivo and in vitro binding of α- and γ-hexachlorocyclohexane to mouse liver macromolecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

25 October 2018

In vivo and in vitro binding of carbon tetrachloride with nucleic acids and proteins in rat and mouse liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567642

25 October 2018

In vivo and in vitro binding of 1,2-dibromoethane and 1,2-dichloroethane to macromolecules in rat and mouse organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of butylated hydroxyanisole on in vivo and in vitro hepatic aflatoxin B1-DNA binding in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro covalent binding of chlorobenzene to nucleic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro binding of benzene to nucleic acids and proteins of various rat and mouse organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotoxicity of 1,1-dichloroethane

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limitations of metabolic activation systems used with in vitro tests for carcinogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of 3,3'-dichlorobenzidine to DNA and polyribonucleotides in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of preneoplastic nodules: quantitative predictivity of carcinogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro binding of epichlorohydrin to nucleic acids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo- in vitro assay for potential carcinogens and mutagens

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison Between Photo-Induction and Microsomal Activation of Polycyclic Hydrocarbons with Different Oncogenic Potency

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism and binding of ( 14 C)mycophenolic acid in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alkylation of phosphates and stability of phosphate triesters in DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsome-dependent binding of benzo(alpha)pyrene and aflatoxin B1 to DNA, and benzo(alpha)pyrene binding to aflatoxin-conjugated DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-enzymatic and microsome-dependent binding of poly-cyclic hydrocarbons to DNA and polynucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Covalent Binding of Bromobenzene with Nucleic Acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of DNA binding activity of perchloroethylene

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The covalent binding of 1, 1,2,2-tetrachloroethane to macromolecules of rat and mouse organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for the deployment of batteries of short-term tests

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of hexachloroethane to biological macromolecules from rat and mouse organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro microsome- and cytosol-mediated binding of 1,2-dichloroethane and 1,2-dibromoethane with DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and DNA binding of 3-methylcholanthrene

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of 3-amino-5H-pyrido[4,3-b]indole, a highly mutagenic principle in tryptophan pyrolysate, by rat liver enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of microsomal dimethylnitrosamine-N-demethylase by pretreatment of mice with acetone

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat liver microsome-mediated binding to DNA of 3-amino-1-methyl-5H-pyrido[4,3-b]indole, a potent mutagen isolated from tryptophan pyrolysate

1 reference

https://pubmed.ncbi.nlm.nih.gov/2351121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1289/EHP.9084183

1 reference

Europe PubMed Central

5 August 2017

1 reference

Europe PubMed Central

5 August 2017

1 reference

Europe PubMed Central

5 August 2017

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