(Q35033814)

5 August 2017

title

Activation of heterotrimeric G proteins by Smoothened (English)

1 reference

5 August 2017

Natalia A Riobo

1

1 reference

5 August 2017

Berangere Saucy

series ordinal

2

1 reference

5 August 2017

Cherisse Dilizio

series ordinal

3

1 reference

5 August 2017

David R Manning

series ordinal

4

1 reference

5 August 2017

language of work or name

English

0 references

publication date

2 August 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

1 reference

5 August 2017

volume

103

1 reference

5 August 2017

issue

33

1 reference

5 August 2017

page(s)

12607-12612

1 reference

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

8 July 2018

1 reference

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Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Transduction of receptor signals by beta-arrestins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Hedgehog signaling and congenital malformations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Hedgehog signalling in cancer formation and maintenance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Analysis of G protein activation in Sf9 and mammalian cells by agonist-promoted [35S]GTP gamma S binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Hedgehog signaling in animal development: paradigms and principles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Vascular smooth muscle growth: autocrine growth mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Sonic hedgehog signaling by the patched-smoothened receptor complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Signal characteristics of G protein-transactivated EGF receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor.G protein coupling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Expression of the human 5-hydroxytryptamine1A receptor in Sf9 cells. Reconstitution of a coupled phenotype by co-expression of mammalian G protein subunits

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0600880103

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0600880103

Measures of efficacy using G proteins as endpoints: differential engagement of G proteins through single receptors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0600880103

Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1567926

Slow muscle induction by Hedgehog signalling in vitro

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16885213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Smoothened activates Galphai-mediated signaling in frog melanophores

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16885213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16885213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0600880103

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference