(Q35035609)

5 August 2017

title

Some reactions and properties of nitro radical-anions important in biology and medicine (English)

1 reference

5 August 2017

Wardman P

1

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5 August 2017

publication date

1 December 1985

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5 August 2017

number of pages

12

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Environmental Health Perspectives

inferred from page(s)

published in

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5 August 2017

volume

64

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5 August 2017

page(s)

309-320

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Mechanisms of cytotoxicity of nitroimidazole drugs.

5 August 2017

cites work

1 reference

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Cellular electron transfer and radical mechanisms for drug metabolism

8 July 2018

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2-Hydroxylaminoimidazoles--unstable intermediates in the reduction of 2-nitroimidazoles

8 July 2018

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Detection of a reactive metabolite of misonidazole in hypoxic mammalian cells

8 July 2018

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Oxygen toxicity, oxygen radicals, transition metals and disease

8 July 2018

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Cis-trans isomerization of the (5-nitro-2-furyl) acrylamide, AF-2, initiated by ascorbate, glutathione, Fe(II) and OH−

8 July 2018

1 reference

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Generation of free radicals induced by nifurtimox in mammalian tissues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

An electron spin resonance investigation and molecular orbital calculation of the anion radical intermediate in the enzymatic cis-trans isomerization of furylfuramide, a nitrofuran derivative of ethylene.

8 July 2018

1 reference

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Selective chemotherapy of noncycling cells in an in vitro tumor model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Reduction of nitroimidazole derivatives by hydrogenosomal extracts of Trichomonas vaginalis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

The Effects of Nitrobenzene Derivatives on Oxygen Utilization and Radiation Response of an in Vitro Tumor Model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Enzymic cis-trans isomerization of nitrofuran derivatives. Isomerizing activity of xanthine oxidase, lipoyl dehydrogenase, DT-diaphorase and liver microsomes

8 July 2018

1 reference

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Correlation between metabolic reduction rates and electron affinity of nitroheterocycles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Sensitization of ultraviolet radiation damage in bacteria and mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

The use of nitroaromatic compounds as hypoxic cell radiosensitizers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Chemical radiosensitization of hypoxic cells and redox potentials: correlation of voltammetric results with pulse radiolysis data of nitro-compounds and radiosensitizers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Electron spin resonance evidence for a free radical intermediate in the cis-trans isomerization of furylfuramide by oxygen-sensitive nitroreductases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

The oxidation of ascorbate by electron affinic drugs and carcinogens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Electron spin resonance-spin trapping. Detection of superoxide formation during aerobic microsomal reduction of nitro-compounds

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

The catalytic effect of the carcinogen “4-nitroquinoline-N-oxide” on the oxidation of vitamin C

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Pulse Radiolysis and ESR Studies of the Electron-Affinic Properties of Nitroheterocyclic Radiosensitizers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Oxygen inhibition of nitroreductase: Electron transfer from nitro radical-anions to oxygen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Ascorbic acid and biological systems. Ascorbic acid and electron transport

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Cis-trans isomerization of nitrofuran derivatives by xanthine oxidase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Glutathione conjugates of misonidazole

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Energetics of the one-electron reduction steps of riboflavin, FMN and FAD to their fully reduced forms.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Pulse radiolysis studies of nitrofurans: chemical radiosensitization.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568617

Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus

25 October 2018

1 reference

12 December 2020

Reductive metabolism and activation of benznidazole

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12 December 2020

Hypoxia-enhanced reduction and covalent binding of [2-3H]misonidazole in the perfused rat liver

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12 December 2020

Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes

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12 December 2020

Chemical modifiers of cancer treatment. Part 1. Banff, Canada, 27 November-1 December, 1983

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12 December 2020

The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system

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12 December 2020

No detectable reaction of the anion radical metabolite of nitrofurans with reduced glutathione or macro-molecules

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12 December 2020

Metronidazole (Flagyl): iron catalysed reaction with sulphydryl groups and tumour radiosensitisation

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12 December 2020

Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells

1 reference

12 December 2020

Protonation of the Radical-anions of Nitro-imidazole Radiosensitizers and the Formation of Radical-adducts

1 reference

12 December 2020

Hypoxic Radiosensitizers and Cellular Respiration

1 reference

12 December 2020

The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes

1 reference

12 December 2020

Anaerobic reduction of nitroimidazoles by reduced flavin mononucleotide and by xanthine oxidase

1 reference

12 December 2020

Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?

1 reference

12 December 2020

Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi

1 reference

12 December 2020

The activity of nitro-compounds against Bacteroides fragilis is related to their electron affinity

1 reference

12 December 2020

Nitroreductase-induced binding of nitroaromatic radiosensitizers to unsaturated lipids

1 reference

12 December 2020

Formation of halide-ions on one-electron reduction of halogenated nitroimidazoles in aqueous solution. A radiolytic study

1 reference

12 December 2020

Conference on chemical modification: radiation and cytotoxic drugs. Key Biscayne, Florida, 17-20 September, 1981

1 reference

12 December 2020

Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations

1 reference

12 December 2020

Reductive fragmentation of 2-nitroimidazoles in the presence of nitroreductases--glyoxal formation from misonidazole

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.8564309

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5 August 2017

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5 August 2017

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