(Q35036570)

5 August 2017

title

Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence (English)

1 reference

Ronald Allan M Panganiban

5 August 2017

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1 reference

object named as

Ronald Allan M Panganiban

series ordinal

1

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author name string

Regina M Day

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

24 October 2013

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5 August 2017

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5 August 2017

volume

8

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5 August 2017

issue

10

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5 August 2017

page(s)

e78589

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Creative Commons CC0 License

5 August 2017

copyright license

start time

24 October 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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Lamin B1 loss is a senescence-associated biomarker.

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8 July 2018

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Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin

8 July 2018

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8 July 2018

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Cell cycle arrest is not senescence

8 July 2018

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DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

8 July 2018

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Weak p53 permits senescence during cell cycle arrest

8 July 2018

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A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation

8 July 2018

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Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

8 July 2018

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Astrocytes regulate the expression of insulin-like growth factor 1 receptor (IGF1-R) in primary cortical neurons during in vitro senescence

8 July 2018

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

8 July 2018

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Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations

8 July 2018

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Growth stimulation leads to cellular senescence when the cell cycle is blocked

8 July 2018

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Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha

8 July 2018

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UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53.

8 July 2018

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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

8 July 2018

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IGF1R signalling and its inhibition

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Accumulation of senescent cells in mitotic tissue of aging primates

8 July 2018

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Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

8 July 2018

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Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells

8 July 2018

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Cellular regulation by hydrogen peroxide

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Antiapoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after gamma-irradiation.

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

The IGF-I receptor in cancer research

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Redox signaling: hydrogen peroxide as intracellular messenger

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Mevalonate-regulated mechanisms in cell growth control: role of dolichyl phosphate in expression of the insulin-like growth factor-1 receptor (IGF-1R) in comparison to Ras prenylation and expression of c-myc

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Secretion of insulinlike growth factor I and insulinlike growth factor-binding proteins by murine bone marrow stromal cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078589

IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078589

Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078589

Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone recepto

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078589

Caspase inhibition switches doxorubicin-induced apoptosis to senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078589

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078589

Differential regulation of apoptotic cell death in senescent human cells.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078589

Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3813482

CaMKII knockdown attenuates H2O2-induced phosphorylation of ERK1/2, PKB/Akt, and IGF-1R in vascular smooth muscle cells

25 October 2018

1 reference

12 December 2020

X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells

1 reference

12 December 2020

Inhibition of N-linked glycosylation using tunicamycin causes cell death in malignant cells: role of down-regulation of the insulin-like growth factor 1 receptor in induction of apoptosis

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12 December 2020

Secretion of IGF-1 by ovine granulosa cells: effects of growth hormone and follicle stimulating hormone

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12 December 2020

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: studies in transgenic mice

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12 December 2020

Analysis of cellular senescence in culture in vivo: the senescence-associated beta-galactosidase assay

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12 December 2020

Insulin-like growth factors and cancer

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12 December 2020

10.1371/JOURNAL.PONE.0078589

Identifiers

DOI

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5 August 2017

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5 August 2017

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