(Q35037678)

5 August 2017

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title

Targeting tumours with genetically enhanced T lymphocytes (English)

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5 August 2017

Michel Sadelain

1

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5 August 2017

Isabelle Rivière

series ordinal

2

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5 August 2017

Renier Brentjens

series ordinal

3

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5 August 2017

language of work or name

English

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publication date

1 January 2003

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5 August 2017

Nature Reviews Cancer

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5 August 2017

3

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5 August 2017

35-45

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5 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrc971

5 August 2017

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cites work

Cancer antigens: immune recognition of self and altered self

1 reference

Progress in human tumour immunology and immunotherapy

21 January 2018

1 reference

Antigens derived from melanocyte differentiation proteins: self-tolerance, autoimmunity, and use for cancer immunotherapy

21 January 2018

1 reference

High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes

21 January 2018

1 reference

Retroviral-mediated gene transfer in primary murine and human T-lymphocytes

21 January 2018

1 reference

CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy

21 January 2018

1 reference

Transfer of specificity by murine alpha and beta T-cell receptor genes

21 January 2018

1 reference

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

21 January 2018

1 reference

Retroviral transduction of a T cell receptor specific for an Epstein-Barr virus-encoded peptide

21 January 2018

1 reference

Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the alpha beta TCR complex

21 January 2018

1 reference

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells

21 January 2018

1 reference

Functional three-domain single-chain T-cell receptors

21 January 2018

1 reference

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR.

21 January 2018

1 reference

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

21 January 2018

1 reference

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

21 January 2018

1 reference

Ligand-mediated cytolysis of tumor cells: use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes

21 January 2018

1 reference

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors

21 January 2018

1 reference

Development and application of receptor-modified T lymphocytes for adoptive immunotherapy.

21 January 2018

1 reference

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

21 January 2018

1 reference

Impact of chimeric immune receptor extracellular protein domains on T cell function

21 January 2018

1 reference

Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes

21 January 2018

1 reference

Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy

21 January 2018

1 reference

Comparison of the TCR zeta-chain with the FcR gamma-chain in chimeric TCR constructs for T cell activation and apoptosis

21 January 2018

1 reference

Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma

21 January 2018

1 reference

T cells engrafted with a recombinant anti-CD30 receptor target autologous CD30(+) cutaneous lymphoma cells

21 January 2018

1 reference

Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene

21 January 2018

1 reference

The use of gene-modified tumor-infiltrating lymphocytes for cancer therapy

21 January 2018

1 reference

CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

21 January 2018

1 reference

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

21 January 2018

1 reference

Functional responses and costimulator dependence of memory CD4+ T cells.

21 January 2018

1 reference

Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen

21 January 2018

1 reference

Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors

21 January 2018

1 reference

Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes.

21 January 2018

1 reference

Regulation of immune responses by TGF-beta

21 January 2018

1 reference

Prostaglandins as modulators of immunity

21 January 2018

1 reference

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

21 January 2018

1 reference

Role of transforming growth factor beta in cancer

21 January 2018

1 reference

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

21 January 2018

1 reference

Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.

21 January 2018

1 reference

Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex.

21 January 2018

1 reference

Suicide gene-mediated modulation of graft-versus-host disease

21 January 2018

1 reference

Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft

21 January 2018

1 reference

Sturm und drang over suicidal lymphocytes

21 January 2018

1 reference

The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes

21 January 2018

1 reference

Bioluminescence imaging of lymphocyte trafficking in vivo.

21 January 2018

1 reference

Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo

21 January 2018

1 reference

Imaging transgene expression with radionuclide imaging technologies

21 January 2018

1 reference

Induction of anti-self-immunity to cure cancer

21 January 2018

1 reference

Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

21 January 2018

1 reference

Immune surveillance against a solid tumor fails because of immunological ignorance

21 January 2018

1 reference

Primary virus-induced lymphomas evade T cell immunity by failure to express viral antigens

21 January 2018

1 reference

Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

1 reference

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

21 January 2018

1 reference

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

21 January 2018

1 reference

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

21 January 2018

1 reference

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

21 January 2018

1 reference

A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

21 January 2018

1 reference

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

21 January 2018

1 reference

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

21 January 2018

1 reference

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

21 January 2018

1 reference

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

21 January 2018

1 reference

T cell activation determined by T cell receptor number and tunable thresholds.

21 January 2018

1 reference

Lymphocyte apoptosis: refining the paths to perdition

21 January 2018

1 reference

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance

21 January 2018

1 reference

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

21 January 2018

1 reference

Cross-presentation, dendritic cells, tolerance and immunity

21 January 2018

1 reference

Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells

21 January 2018

1 reference

Recognition of human colon cancer by T cells transduced with a chimeric receptor gene

21 January 2018

1 reference

Anti-Tumor CC49-zeta CD4 T cells possess both cytolytic and helper functions.

21 January 2018

1 reference

Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors

21 January 2018

1 reference

Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production

21 January 2018

1 reference

Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules

21 January 2018

1 reference

Specific targeting of EGP-2+ tumor cells by primary lymphocytes modified with chimeric T cell receptors

21 January 2018

1 reference

Generation of gene-modified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature

21 January 2018

1 reference

Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors

21 January 2018

1 reference

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

21 January 2018

1 reference

Redirected Perforin-Dependent Lysis of Colon Carcinoma by Ex Vivo Genetically Engineered CTL

21 January 2018

1 reference

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

21 January 2018

1 reference

21 January 2018

Cancer Tumor antigens

1 reference

Immunotherapy through TCR gene transfer

21 January 2018

1 reference

Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor

21 January 2018

1 reference

A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-gamma chain chimeric receptor gene recognizing a human ovarian cancer antigen

21 January 2018

1 reference

Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule

21 January 2018

1 reference

Dynamics of tumor cell killing by human T lymphocytes armed with an anti-carcinoembryonic antigen chimeric immunoglobulin T-cell receptor

21 January 2018

1 reference

Costimulatory approaches to adoptive immunotherapy.

21 January 2018

1 reference

The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells

21 January 2018

1 reference

Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2

21 January 2018

1 reference

Preoperative plasma levels of transforming growth factor beta(1) (TGF-beta(1)) strongly predict progression in patients undergoing radical prostatectomy

21 January 2018

1 reference

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

21 January 2018

1 reference

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

21 January 2018

1 reference

T lymphocyte costimulation mediated by reorganization of membrane microdomains

21 January 2018

1 reference

Rejection of mouse cardiac allografts by costimulation in trans

21 January 2018

1 reference

Coupling CD28 co-stimulation to immunoglobulin T-cell receptor molecules: the dynamics of T-cell proliferation and death

21 January 2018

1 reference

Expansion and characterization of T cells transduced with a chimeric receptor against ovarian cancer

21 January 2018

1 reference

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Imaging transgene expression for gene therapy

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC971

1 reference

5 August 2017

1 reference