(Q35039858)

5 August 2017

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title

The pleiotropic effects of HMG-CoA reductase inhibitors: their role in osteoporosis and dementia (English)

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5 August 2017

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Alla Waldman

1

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5 August 2017

Leonard Kritharides

series ordinal

2

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5 August 2017

language of work or name

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1 January 2003

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5 August 2017

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5 August 2017

volume

63

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5 August 2017

issue

2

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5 August 2017

page(s)

139-152

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Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis

5 August 2017

cites work

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12 December 2020

Untangling vascular dementia.

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12 December 2020

Regulation of the mevalonate pathway

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12 December 2020

Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia

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12 December 2020

Hydroxypropyl-beta-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells

1 reference

12 December 2020

HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients

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12 December 2020

Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes

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12 December 2020

In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

1 reference

12 December 2020

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

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12 December 2020

Statins and the risk of dementia

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12 December 2020

Poststroke dementia: incidence and relationship to prestroke cognitive decline.

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12 December 2020

Inverse relationship between circulating levels of leptin and bone mineral density in chronic liver disease

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12 December 2020

Early effects of raloxifene on clinical vertebral fractures at 12 months in postmenopausal women with osteoporosis

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12 December 2020

Use of statins and risk of fractures

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12 December 2020

Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease

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12 December 2020

Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women

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12 December 2020

Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences

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12 December 2020

The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators

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12 December 2020

Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide

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12 December 2020

Improvement of coronary vasodilatation capacity through single LDL apheresis

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12 December 2020

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

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12 December 2020

Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.

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12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

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12 December 2020

Apheresis technology for prevention and regression of atherosclerosis.

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12 December 2020

Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier

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12 December 2020

Pleiotropic effects of statins and their clinical significance

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12 December 2020

Genetic control of bone remodeling--insights from a rare disease

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12 December 2020

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

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12 December 2020

Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

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12 December 2020

Current concepts in the pathogenesis of Alzheimer's disease

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12 December 2020

Cellular cholesterol efflux mediated by cyclodextrins

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12 December 2020

Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study

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12 December 2020

Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study

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12 December 2020

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12 December 2020

Statin therapy and the prevention of dementia

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12 December 2020

Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study

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12 December 2020

Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study

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12 December 2020

Effects of lovastatin on cognitive function and psychological well-being

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12 December 2020

Cholesterol metabolism in the brain

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12 December 2020

Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS).

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12 December 2020

Pravastatin Therapy and the Risk of Stroke

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12 December 2020

Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells

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12 December 2020

Lipid-lowering trials in the primary and secondary prevention of coronary heart disease: new evidence, implications and outstanding issues.

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12 December 2020

Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?

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12 December 2020

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

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12 December 2020

Safety, tolerability, and pharmacokinetics of an extended-release formulation of fluvastatin administered once daily to patients with primary hypercholesterolemia

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12 December 2020

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

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12 December 2020

Effect of Anti-inflammatory Medications on Neuropathological Findings in Alzheimer Disease

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12 December 2020

Effects of 1-year treatment with fluvastatin or pravastatin on bone

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12 December 2020

The socioeconomic burden of fractures: today and in the 21st century

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12 December 2020

HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients

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12 December 2020

Recent advances in multifactorial regulation of vascular calcification.

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12 December 2020

Stimulation of bone formation in vitro and in rodents by statins

1 reference

12 December 2020

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

1 reference

12 December 2020

Clinically relevant differences between the statins: implications for therapeutic selection

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Statins as a newly recognized type of immunomodulator

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12 December 2020

Treatment of postmenopausal osteoporosis

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12 December 2020

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

12 December 2020

Central control of bone mass: brainstorming of the skeleton.

1 reference

12 December 2020

Changes in proinflammatory cytokine activity after menopause

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12 December 2020

Neuropathological assessment of the lesions of significance in vascular dementia

1 reference

12 December 2020

Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: the Prospective Pravastatin Pooling Project

1 reference

12 December 2020

Antiatherothrombotic properties of statins: implications for cardiovascular event reduction

1 reference

12 December 2020

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

1 reference

12 December 2020

The design of a prospective study of pravastatin in the elderly at risk (PROSPER)

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12 December 2020

Cardiovascular disease and osteoporosis: is there a link between lipids and bone?

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12 December 2020

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol

1 reference

12 December 2020

Simvastatin, an HMG-CoA reductase inhibitor, induces the synthesis and secretion of apolipoprotein AI in HepG2 cells and primary hamster hepatocytes

1 reference

12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

12 December 2020

HMG-CoA reductase inhibitors and the risk of fractures

1 reference

12 December 2020

New insights into the pharmacodynamic and pharmacokinetic properties of statins.

1 reference

12 December 2020

Epidemiology and predictors of fractures associated with osteoporosis

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12 December 2020

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

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12 December 2020

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

1 reference

12 December 2020

Effect of simvastatin on bone markers in osteopenic women: a placebo-controlled, dose-ranging trial [ISRCTN85429598]

1 reference

12 December 2020

Clinically relevant pleiotropic effects of statins: drug properties or effects of profound cholesterol reduction?

1 reference

12 December 2020

Alzheimer's disease: its diagnosis and pathogenesis.

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12 December 2020

Clinical pharmacokinetics of pravastatin

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12 December 2020

Clinical review 123: Anabolic therapy for osteoporosis

1 reference

12 December 2020

Leptin enhances the calcification of vascular cells: artery wall as a target of leptin

1 reference

12 December 2020

Dementia and its associations in type 2 diabetes mellitus: the Fremantle Diabetes Study.

1 reference

12 December 2020

An overview of common non-Alzheimer dementias

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12 December 2020

Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients.

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12 December 2020

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

1 reference

12 December 2020

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

1 reference

12 December 2020

Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators

1 reference

12 December 2020

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

1 reference

12 December 2020

Pseudocapillarization and associated energy limitation in the aged rat liver

1 reference

12 December 2020

Pleiotropic effects of statins: do they matter?

1 reference

12 December 2020

Immunomodulation: a new role for statins?

1 reference

12 December 2020

Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

1 reference

12 December 2020

Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain

1 reference

12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Oral statins and increased bone-mineral density in postmenopausal women

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12 December 2020

10.2165/00003495-200363020-00002

Identifiers

DOI

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Dimensions Publication ID

5 August 2017

1035463068

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