(Q35040959)

6 August 2017

title

Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases (English)

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6 August 2017

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John M Denu

1

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6 August 2017

publication date

1 January 2003

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6 August 2017

number of pages

8

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Trends in Biochemical Sciences

inferred from page(s)

published in

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6 August 2017

volume

28

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6 August 2017

issue

1

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6 August 2017

page(s)

41-48

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Histone acetyltransferases

6 August 2017

cites work

1 reference

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7 January 2021

Global histone acetylation and deacetylation in yeast

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7 January 2021

Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases

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7 January 2021

Histone modifications in transcriptional regulation

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7 January 2021

Translating the Histone Code

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7 January 2021

Chromatin remodeling: nucleosomes bulging at the seams

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7 January 2021

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

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7 January 2021

Role of NAD(+) in the deacetylase activity of the SIR2-like proteins

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7 January 2021

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

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7 January 2021

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

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7 January 2021

Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

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7 January 2021

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

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7 January 2021

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

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7 January 2021

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

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7 January 2021

Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA.

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7 January 2021

An unusual form of transcriptional silencing in yeast ribosomal DNA

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Silencing and heritable domains of gene expression

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.

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7 January 2021

Common themes in mechanisms of gene silencing

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity

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7 January 2021

Extrachromosomal rDNA circles--a cause of aging in yeast

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7 January 2021

SIR2 and aging--the exception that proves the rule.

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7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry

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7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

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7 January 2021

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

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7 January 2021

The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation

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7 January 2021

CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis i

1 reference

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7 January 2021

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Crystal structure of a SIR2 homolog-NAD complex

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Structure of the histone deacetylase SIRT2

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Structural basis for the NAD-dependent deacetylase mechanism of Sir2

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

The molecular biology of the SIR proteins

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

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https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2900005-1

7 January 2021

The impact energy metabolism and genome maintenance have on longevity and senescence: lessons from yeast to mammals

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7 January 2021

New functions of a long-known molecule. Emerging roles of NAD in cellular signaling

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7 January 2021

10.1016/S0968-0004(02)00005-1

Identifiers

DOI

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6 August 2017

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