(Q35042403)

English

On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone.

scientific article published in July 2000

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882398%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882398%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

David G Lambert

3

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8 November 2019

Atticus H Hainsworth

4

1 reference

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8 November 2019

author name string

R M Nelson

1

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8 November 2019

A R Green

2

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8 November 2019

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1 July 2000

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8 November 2019

British Journal of Pharmacology

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8 November 2019

130

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8 November 2019

5

1 reference

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8 November 2019

1124-1130

1 reference

Europe PubMed Central

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8 November 2019

GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

The metabolism of clomethiazole in gerbils and the neuroprotective and sedative activity of the metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Pathobiology of ischaemic stroke: an integrated view

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

The changing landscape of ischaemic brain injury mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Intrinsic optical signaling denoting neuronal damage in response to acute excitotoxic insult by domoic acid in the hippocampal slice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Calcium in ischemic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Interactions between loreclezole, chlormethiazole and pentobarbitone at GABA(A) receptors: functional and binding studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

GABA and neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

NMDA antagonists: their role in neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Techniques for assessing neuroprotective drugs in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Techniques for examining neuroprotective drugs in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

mu- and kappa-opioids inhibit K+ evoked glutamate release from rat cerebrocortical slices.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

The human neuroblastoma cell line, IMR-32 possesses a GABAA receptor lacking the benzodiazepine modulatory site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Two distinct interactions of barbiturates and chlormethiazole with the GABAA receptor complex in rat cuneate nucleus in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Ca2+-dependent and Ca2+-independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: possible relevance to hypoglycaemia and anoxia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Rodent models of cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

The modulation by chlormethiazole of the GABAA-receptor complex in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

8 July 2018

Activation of cPLA2, PKC, and ERKs in the rat cerebral cortex during ischemia/reperfusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Vicious cycle involving Na+ channels, glutamate release, and NMDA receptors mediates delayed neurodegeneration through nitric oxide formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Hippocampal slices: glutamate overflow and cellular damage from ischemia are reduced by sodium-channel blockade.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

The immediate consequences of middle cerebral artery occlusion on GABA synthesis in mouse cortex and cerebellum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572159

25 October 2018

Modulation of GABAA and glycine receptors by chlormethiazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling among energy failure, loss of ion homeostasis, and phospholipase A2 and C activation during ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino-acid release from human cerebral cortex during simulated ischaemia in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection for acute stroke: making clinical trials work

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular picrotoxin blocks pentobarbital-gated Cl- conductance

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for gamma-aminobutyric acid in selective vulnerability in gerbils

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/10882398

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0703398

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882398%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882398%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10882398%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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