(Q35044257)

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Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in models of airway inflammation

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in models of airway inflammation (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Thomas H. Keller

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

author name string

Alexandre Trifilieff

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Christoph Walker

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Georg Kottirsch

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Ulf Neumann

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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1 April 2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

British Journal of Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

135

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1655-1664

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Modulation of allergic inflammation in mice deficient in TNF receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Effect of the p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Regulation of matrix metalloproteinases and their inhibitor genes in lipopolysaccharide-induced endotoxemia in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Tissue remodeling as a feature of persistent asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

The locus of tumor necrosis factor-alpha action in lung inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Structural and inflammatory changes in COPD: a comparison with asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Tumour necrosis factor alpha: a potential mediator of asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

TH2 and 'TH2-like' cells in allergy and asthma: pharmacological perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

T cell gelatinases mediate basement membrane transmigration in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Effect of tumor necrosis factor receptor binding protein on cell infiltration induced by lipopolysaccharide and Sephadex beads in guinea pig lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Mucosal inflammation in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Tumor Necrosis Factor Causes Bronchial Hyperresponsiveness in Rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

8 July 2018

Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0704616

21 January 2018

TNF-alpha and IL-1 beta are not essential to the inflammatory response in LPS-induced airway disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

25 October 2018

Pharmacological evidence for tumor necrosis factor as a mediator of allergic inflammation in the airways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

25 October 2018

Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

25 October 2018

Thioester hydrolysis by matrix metalloproteinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

25 October 2018

A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573282

9 December 2018

Increased expression of functionally active membrane-associated tumor necrosis factor in acute respiratory distress syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shedding of the lymphocyte L-selectin adhesion molecule is inhibited by a hydroxamic acid-based protease inhibitor. Identification with an L-selectin-alkaline phosphatase reporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Metalloproteases in the Release of the IL-1 type II Decoy Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for ectodomain shedding in mammalian development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of tumour necrosis factor-α precursor by metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster

1 reference

https://pubmed.ncbi.nlm.nih.gov/11934805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0704616

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11934805%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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