(Q35044558)

6 August 2017

1 reference

title

The structure and function of drug pumps: an update (English)

1 reference

6 August 2017

Kenneth S McKeegan

1

1 reference

6 August 2017

M Ines Borges-Walmsley

series ordinal

2

1 reference

6 August 2017

Adrian R Walmsley

series ordinal

3

1 reference

6 August 2017

publication date

1 January 2003

1 reference

6 August 2017

published in

Trends in Microbiology

1 reference

6 August 2017

volume

11

1 reference

6 August 2017

issue

1

1 reference

6 August 2017

page(s)

21-29

1 reference

The structure and function of drug pumps

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Crystal structure of bacterial multidrug efflux transporter AcrB

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Structural mechanisms of QacR induction and multidrug recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

P-glycoprotein and multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Expression and characterization of DrrA and DrrB proteins of Streptomyces peucetius in Escherichia coli: DrrA is an ATP binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Biochemical coupling between the DrrA and DrrB proteins of the doxorubicin efflux pump of Streptomyces peucetius

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The structure of the multidrug resistance protein 1 (MRP1/ABCC1). crystallization and single-particle analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Three-dimensional structure by cryo-electron microscopy of YvcC, an homodimeric ATP-binding cassette transporter from Bacillus subtilis

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Three-dimensional structure of transporter associated with antigen processing (TAP) obtained by single Particle image analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

ATPase activity of the MsbA lipid flippase of Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Crystal structure of the ATP-binding subunit of an ABC transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Unisite and multisite catalysis in the ArsA ATPase.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Evaluation of a structural model of Pseudomonas aeruginosa outer membrane protein OprM, an efflux component involved in intrinsic antibiotic resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Crystal structure of the transcription activator BmrR bound to DNA and a drug

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Purification and ligand binding of EmrR, a regulator of a multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

The purified and functionally reconstituted multidrug transporter LmrA of Lactococcus lactis mediates the transbilayer movement of specific fluorescent phospholipids.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

Communication between multiple drug binding sites on P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2802%2900010-0

7 January 2021

10.1016/S0966-842X(02)00010-0

Identifiers

DOI

1 reference

6 August 2017

1 reference