(Q35048852)

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A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity

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Europe PubMed Central

PubMed publication ID

6 August 2017

A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

Karl Ziegelbauer

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Florian Gantner

2

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Europe PubMed Central

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6 August 2017

Nicholas W Lukacs

3

1 reference

Europe PubMed Central

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6 August 2017

Aaron Berlin

4

1 reference

Europe PubMed Central

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6 August 2017

Kinji Fuchikami

5

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Toshiro Niki

6

1 reference

Europe PubMed Central

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6 August 2017

Katsuya Sakai

7

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Hisayo Inbe

8

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Keisuke Takeshita

9

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Mina Ishimori

10

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Hiroshi Komura

11

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Toshiki Murata

12

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Timothy Lowinger

13

1 reference

Europe PubMed Central

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6 August 2017

Kevin B Bacon

14

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6 August 2017

language of work or name

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publication date

1 May 2005

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Europe PubMed Central

PubMed publication ID

6 August 2017

British Journal of Pharmacology

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Europe PubMed Central

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6 August 2017

145

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Europe PubMed Central

PubMed publication ID

6 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

178-192

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

IkappaB kinases: key regulators of the NF-kappaB pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

IKK2 inhibitor alleviates kidney and wasting diseases in a murine model of human AIDS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

The IKK NF-kappa B system: a treasure trove for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Mechanisms of severe asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Novel IKK inhibitors: beta-carbolines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Update on glucocorticoid action and resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

IkappaB kinase signaling is essential for maintenance of mature B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

The burden of asthma with specific reference to the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Missing pieces in the NF-kappaB puzzle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

NF-kappa B as a therapeutic target in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

IL-4 signaling, gene transcription regulation, and the control of effector T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

IKKalpha controls formation of the epidermis independently of NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

The role of nuclear factor-kappa B in pulmonary diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Mechanisms of eosinophil-associated inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Proteasome inhibition: A novel mechanism to combat asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Limb and skin abnormalities in mice lacking IKKalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Activation and localization of transcription factor, nuclear factor-kappaB, in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

NF-kappa B: a pivotal role in asthma and a new target for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

8 July 2018

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 2: Improvement of in vitro activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576128

25 October 2018

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The allergen Der p1 induces NF-kappaB activation through interference with IkappaB alpha function in asthmatic bronchial epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of topically applied cyclooxygenase-2-selective inhibitors on arachidonic acid- and tetradecanoylphorbol acetate-induced dermal inflammation in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of nuclear transcription factor kappaB in rat carrageenin-induced pleurisy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IKKβ Is Required for Peripheral B Cell Survival and Proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/15753951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kB: a pivotal role in asthma and a new target for therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0706176

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.BJP.0706176

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

ResearchGate publication ID

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