(Q35049475)

6 August 2017

title

Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis (English)

1 reference

6 August 2017

1 reference

Zili Zhang

1

1 reference

6 August 2017

Qi Liu

2

1 reference

6 August 2017

Konstantin S Leskov

3

1 reference

6 August 2017

Xiumei Wu

4

1 reference

6 August 2017

Jie Duan

5

1 reference

6 August 2017

Gary L Zhang

6

1 reference

6 August 2017

Mark Hall

7

1 reference

6 August 2017

James T Rosenbaum

8

1 reference

6 August 2017

language of work or name

English

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publication date

18 November 2013

1 reference

6 August 2017

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6 August 2017

volume

8

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6 August 2017

issue

11

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6 August 2017

page(s)

e81154

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Creative Commons Attribution 3.0 Unported

6 August 2017

copyright license

start time

18 November 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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8 July 2018

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Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis

8 July 2018

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Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.

8 July 2018

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Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis

8 July 2018

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Control of immunity by the TNFR-related molecule OX40 (CD134)

8 July 2018

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Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation

8 July 2018

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Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle

8 July 2018

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The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1.

8 July 2018

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8 July 2018

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8 July 2018

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Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

8 July 2018

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Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion

8 July 2018

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8 July 2018

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Activation-induced cell death

8 July 2018

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IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production.

8 July 2018

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Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-beta-treated alloreactive T cells that do not induce graft-versus-host disease

8 July 2018

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Cell-cycle regulation in immunity, tolerance and autoimmunity

8 July 2018

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Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle

8 July 2018

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Helper T cell differentiation is controlled by the cell cycle

8 July 2018

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Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

8 July 2018

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8 July 2018

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

8 July 2018

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3832440

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3832440

Fas ligand mediates activation-induced cell death in human T lymphocytes

8 July 2018

1 reference

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The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes

8 July 2018

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A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

21 January 2018

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The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081154

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081154

OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081154

Antigen-specific accumulation of naïve, memory and effector CD4 T cells during anterior uveitis monitored by intravital microscopy.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081154

High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081154

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081154

Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity.

21 January 2018

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A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens

25 October 2018

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Intraocular in vivo imaging of activated T-lymphocytes expressing green-fluorescent protein after stimulation with endotoxin

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24260551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24260551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24260551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0081154

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference