(Q35157537)

6 August 2017

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title

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer (English)

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6 August 2017

3

Zwi N Berneman

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author name string

Katrien Vermeulen

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

Dirk R Van Bockstaele

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

Zwi N Berneman

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

publication date

1 June 2003

1 reference

6 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

volume

36

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

page(s)

131-149

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

Cyclin-dependent kinase inhibitors and human cancer.

14 May 2020

cites work

1 reference

12 December 2020

Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

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12 December 2020

Principles of CDK regulation

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12 December 2020

Concurrent disruption of cell cycle associated genes in mantle cell lymphoma: a genotypic and phenotypic study of cyclin D1, p16, p15, p53 and pRb.

1 reference

12 December 2020

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1 reference

12 December 2020

Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control

1 reference

12 December 2020

Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action

1 reference

12 December 2020

Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.

1 reference

12 December 2020

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

12 December 2020

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis

1 reference

12 December 2020

Cyclins and cyclin-dependent kinases: theme and variations

1 reference

12 December 2020

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution

1 reference

12 December 2020

Inhibitors of the Cip/Kip family.

1 reference

12 December 2020

Interaction of HPV E6 with p53 and associated proteins

1 reference

12 December 2020

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1 reference

12 December 2020

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma.

1 reference

12 December 2020

Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

1 reference

12 December 2020

Control of Cell Division by Very Lysine Rich Histone (F1) Phosphorylation

1 reference

12 December 2020

Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

1 reference

12 December 2020

Genetics and cytogenetics of retinoblastoma

1 reference

12 December 2020

How proteolysis drives the cell cycle

1 reference

12 December 2020

p53, the cellular gatekeeper for growth and division

1 reference

12 December 2020

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

1 reference

12 December 2020

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase

1 reference

12 December 2020

Mitosis in transition

1 reference

12 December 2020

Inhibition of cyclin-dependent kinases by purine analogues.

1 reference

12 December 2020

Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles

1 reference

12 December 2020

Inhibition of cyclin-dependent kinases by p21

1 reference

12 December 2020

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

1 reference

12 December 2020

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2

1 reference

12 December 2020

Cell cycle regulation by the ubiquitin pathway

1 reference

12 December 2020

Cyclin is degraded by the ubiquitin pathway

1 reference

12 December 2020

Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.

1 reference

12 December 2020

Quinazolines as cyclin dependent kinase inhibitors

1 reference

12 December 2020

Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies

1 reference

12 December 2020

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

12 December 2020

Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas

1 reference

12 December 2020

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

12 December 2020

Inhibition of mammalian cell DNA synthesis by ionizing radiation

1 reference

12 December 2020

Cyclin G is a transcriptional target of the p53 tumor suppressor protein

1 reference

12 December 2020

Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development

1 reference

12 December 2020

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

12 December 2020

Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

1 reference

12 December 2020

Checkpoints: controls that ensure the order of cell cycle events

1 reference

12 December 2020

Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol

1 reference

12 December 2020

Tumor suppressor gene alteration in adult acute lymphoblastic leukemia (ALL). Analysis of retinoblastoma (Rb) and p53 gene expression in lymphoblasts of patients with de novo, relapsed, or refractory ALL treated in Southwest Oncology Group studies.

1 reference

12 December 2020

Suramin: an anticancer drug with unique biological effects

1 reference

12 December 2020

Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases

1 reference

12 December 2020

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import

1 reference

12 December 2020

Preclinical and clinical development of cyclin-dependent kinase modulators

1 reference

12 December 2020

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

1 reference

12 December 2020

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

12 December 2020

CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation

1 reference

12 December 2020

p53 status and the efficacy of cancer therapy in vivo

1 reference

12 December 2020

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

12 December 2020

The INK4 family of CDK inhibitors.

1 reference

12 December 2020

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

12 December 2020

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

1 reference

12 December 2020

A Restriction Point for Control of Normal Animal Cell Proliferation

1 reference

12 December 2020

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

1 reference

12 December 2020

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

1 reference

12 December 2020

Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions

1 reference

12 December 2020

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

12 December 2020

Synthesis and biological activity of olomoucine II.

1 reference

12 December 2020

Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells

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12 December 2020

Deregulation of cyclin E in breast cancer

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12 December 2020

Active cyclin A-CDK2 complex, a possible critical factor for cell proliferation in human primary lung carcinomas

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12 December 2020

Association between the cellular p53 and the adenovirus 5 E1B-55kd proteins reduces the oncogenicity of Ad-transformed cells.

1 reference

12 December 2020

Cell cycle regulation by the Cdc25 phosphatase family

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12 December 2020

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

12 December 2020

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1 reference

12 December 2020

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas

1 reference

12 December 2020

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

1 reference

12 December 2020

The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics

1 reference

12 December 2020

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

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12 December 2020

A p18 mutant defective in CDK6 binding in human breast cancer cells

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12 December 2020

PEST sequences and regulation by proteolysis

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12 December 2020

Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines

1 reference

12 December 2020

Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.

1 reference

12 December 2020

The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase

1 reference

12 December 2020

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer

1 reference

12 December 2020

p53-induced p21 controls DNA replication

1 reference

12 December 2020

Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage

1 reference

12 December 2020

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

1 reference

12 December 2020

CDK inhibitor shows promise for inflammatory kidney disease

1 reference

12 December 2020

Plant cytokinin analogues with inhibitory activity on cyclin-dependent kinases exert their antiproliferative effect through induction of apoptosis initiated by the mitochondrial pathway: determination by a multiparametric flow cytometric analysis

1 reference

12 December 2020

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer

1 reference

12 December 2020

Mutation and cancer: statistical study of retinoblastoma

1 reference

12 December 2020

Cdk inhibitors in development and cancer

1 reference

12 December 2020

P53 mutations in human cancer

1 reference

12 December 2020

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product

1 reference

12 December 2020

Regulation of the G2/M transition by p53.

1 reference

12 December 2020

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1 reference

12 December 2020

Phosphorylation of DNA polymerase alpha-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro

1 reference

12 December 2020

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1 reference

12 December 2020

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

1 reference

12 December 2020

Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells

1 reference

12 December 2020

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

12 December 2020

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

1 reference

12 December 2020

Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases

1 reference

12 December 2020

The spindle checkpoint

1 reference

12 December 2020

A model for p53-induced apoptosis

1 reference

12 December 2020

Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein

1 reference

12 December 2020

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1 reference

12 December 2020

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

1 reference

12 December 2020

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations

1 reference

12 December 2020

Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21

1 reference

12 December 2020

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

1 reference

12 December 2020

Inhibition of p53 Protein Phosphorylation by 9‐Hydroxyellipticine: A Possible Anticancer Mechanism

1 reference

12 December 2020

Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage

1 reference

12 December 2020

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis

1 reference

12 December 2020

Abnormal expression of MDM-2 in breast carcinomas

1 reference

12 December 2020

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

1 reference

12 December 2020

Identification of a cyclin subunit required for the function of Drosophila P-TEFb

1 reference

12 December 2020

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

1 reference

12 December 2020

A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells

1 reference

12 December 2020

An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cells.

1 reference

12 December 2020

A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase

1 reference

12 December 2020

Cell cycle control as a basis for cancer drug development (Review).

1 reference

12 December 2020

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1 reference

12 December 2020

Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II

1 reference

12 December 2020

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

1 reference

12 December 2020

Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine

1 reference

12 December 2020

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage.

1 reference

12 December 2020

Synthesis and antitumor activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones

1 reference

12 December 2020

1 reference

12 December 2020

Intermediate lymphocytic lymphoma: immunophenotypic and cytogenetic findings.

1 reference

12 December 2020

Role for cyclin A in the dependence of mitosis on completion of DMA replication

1 reference

12 December 2020

WAF1, a potential mediator of p53 tumor suppression

1 reference

12 December 2020

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1 reference

12 December 2020

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

1 reference

12 December 2020

Cdc25 cell-cycle phosphatase as a target of c-myc

1 reference

12 December 2020

Cyclins: wheels within wheels

1 reference

12 December 2020

A novel cyclin encoded by a bcl1-linked candidate oncogene

1 reference

12 December 2020

A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression.

1 reference

12 December 2020

p53: puzzle and paradigm

1 reference

12 December 2020

Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase

1 reference

12 December 2020

Multiple patterns of MDM-2 deregulation in human leukemias: implications in leukemogenesis and prognosis

1 reference

12 December 2020

Regulation of the p53 tumor suppressor protein

1 reference

12 December 2020

Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity

1 reference

12 December 2020

Animal cell cycles and their control

1 reference

12 December 2020

G1 phase progression: cycling on cue

1 reference

12 December 2020

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

1 reference

12 December 2020

Overexpression of cyclin E in acute myelogenous leukemia

1 reference

12 December 2020

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

12 December 2020

28 Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

1 reference

12 December 2020

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

1 reference

12 December 2020

1 reference

12 December 2020

Amplification of cyclin genes in colorectal carcinomas

1 reference

12 December 2020

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

1 reference

12 December 2020

Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717

1 reference

12 December 2020

DNA-dependent protein kinase-independent activation of p53 in response to DNA damage

1 reference

12 December 2020

A new screening test for antimitotic compounds using the universal M phase-specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilized on p13suc1-coated microtitration plates

1 reference

12 December 2020

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties

1 reference

12 December 2020

Regulation of CDK/cyclin complexes during the cell cycle

1 reference

12 December 2020

Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

1 reference

12 December 2020

Mutations and altered expression of p16INK4 in human cancer.

1 reference

12 December 2020

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

12 December 2020

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities

1 reference

12 December 2020

Retinoblastoma protein recruits histone deacetylase to repress transcription

1 reference

12 December 2020

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

1 reference

12 December 2020

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1 reference

12 December 2020

Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

1 reference

12 December 2020

Amplified CDK2 and cdc2 activities in primary colorectal carcinoma

1 reference

12 December 2020

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1 reference

12 December 2020

Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase

1 reference

12 December 2020

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

12 December 2020

p53 gene mutations and photocarcinogenesis

1 reference

12 December 2020

Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex

1 reference

12 December 2020

1 reference

12 December 2020

6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity.

1 reference

12 December 2020

The retinoblastoma protein pathway and the restriction point

1 reference

12 December 2020

Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases

1 reference

12 December 2020

UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

1 reference

12 December 2020

10.1046/J.1365-2184.2003.00266.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496723&resulttype=core&format=json

14 May 2020

12814430

1 reference