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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
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Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
review article
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Europe PubMed Central
title
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
main subject
DNA damage
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author
Daniel Durocher
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1
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Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
Stephen P Jackson
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2
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Europe PubMed Central
PubMed publication ID
11248557
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
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5 November 2019
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Durocher D
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1
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Europe PubMed Central
PubMed publication ID
11248557
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31 July 2017
Jackson SP
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2
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Europe PubMed Central
PubMed publication ID
11248557
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31 July 2017
publication date
1 April 2001
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Europe PubMed Central
PubMed publication ID
11248557
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retrieved
5 November 2019
published in
Current Opinion in Cell Biology
1 reference
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Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
volume
13
1 reference
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Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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2
1 reference
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Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
page(s)
225-231
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Europe PubMed Central
PubMed publication ID
11248557
reference URL
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retrieved
5 November 2019
cites work
Yeast checkpoint genes in DNA damage processing: implications for repair and arrest
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sensing and responding to DNA damage.
1 reference
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Crossref
reference URL
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7 January 2021
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Checkpoints: How to activate p53
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid destruction of human Cdc25A in response to DNA damage
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 in response to DNA damage
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Cell cycle checkpoints: preventing an identity crisis
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Crossref
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7 January 2021
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Defying death after DNA damage.
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7 January 2021
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DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
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Crossref
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7 January 2021
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The DNA-dependent protein kinase
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase-independent activation of p53 in response to DNA damage
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Substrate specificities and identification of putative substrates of ATM kinase family members
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atm-deficient mice: a paradigm of ataxia telangiectasia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Radiosensitivity in ataxia-telangiectasia: a new explanation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced phosphorylation of p53 by ATM in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for ATR in the DNA damage-induced phosphorylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensor-less checkpoint activation?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for Saccharomyces cerevisiae histone H2A in DNA repair.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Megabase chromatin domains involved in DNA double-strand breaks in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0955-0674%2800%2900201-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0955-0674(00)00201-5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
PubMed publication ID
11248557
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11248557
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248557%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
ResearchGate publication ID
222554160
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