(Q50722584)

18 March 2018

title

Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. (English)

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18 March 2018

author name string

Costanzo V

1

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18 March 2018

Robertson K

2

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18 March 2018

Ying CY

3

1 reference

18 March 2018

Kim E

4

1 reference

18 March 2018

Avvedimento E

5

1 reference

18 March 2018

Gottesman M

6

1 reference

18 March 2018

Grieco D

7

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18 March 2018

Gautier J

8

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18 March 2018

publication date

1 September 2000

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18 March 2018

published in

Molecular Cell

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18 March 2018

volume

6

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18 March 2018

page(s)

649-659

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18 March 2018

issue

3

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18 March 2018

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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7 January 2021

Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation

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7 January 2021

The Schizosaccharomyces pombe rad3 checkpoint gene

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Caffeine inhibits the checkpoint kinase ATM

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cell cycle. Piecing together the p53 puzzle.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Purification of an MCM-containing complex as a component of the DNA replication licensing system.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Characterization of the Xenopus replication licensing system.

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Protein Kinase A is required for chromosomal DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cell cycle checkpoints: preventing an identity crisis

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Inhibition of cyclin-dependent kinases by p21

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https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Regulation of cell cycle progression following DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

A developmental timer that regulates apoptosis at the onset of gastrulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Early events in DNA replication require cyclin E and are blocked by p21CIP1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

ATM associates with and phosphorylates p53: mapping the region of interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

A maternal form of the phosphatase Cdc25A regulates early embryonic cell cycles in Xenopus laevis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Radiation down-regulates replication origin activity throughout the S phase in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

The genetic defect in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Rapid destruction of human Cdc25A in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Putting it all together: building a prereplicative complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Maternal Xenopus Cdk2-cyclin E complexes function during meiotic and early embryonic cell cycles that lack a G1 phase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cdc7 protein kinase for DNA metabolism comes of age.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cell cycle control by Xenopus p28Kix1, a developmentally regulated inhibitor of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Developmental regulation of MCM replication factors in Xenopus laevis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Influence of ATM function on telomere metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cell cycle control of DNA replication.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

An analysis of the regulation of DNA synthesis by cdk2, Cip1, and licensing factor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2800%2900063-0

7 January 2021

10.1016/S1097-2765(00)00063-0

Identifiers

DOI

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18 March 2018

PubMed ID

11030344

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18 March 2018