(Q35050603)

6 August 2017

1 reference

title

Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors (English)

1 reference

6 August 2017

0 references

1

Bruce Beutler

1 reference

6 August 2017

publication date

10 January 2002

1 reference

Annual Review of Pharmacology and Toxicology

6 August 2017

number of pages

20

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

6 August 2017

volume

43

1 reference

6 August 2017

page(s)

609-628

1 reference

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

6 August 2017

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.282.5396.2085

Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1006/BCMD.1998.0201

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Lipid A: Chemical Structure and Biological Activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Divergent evolution of plant NBS-LRR resistance gene homologues in dicot and cereal genomes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

E5531, a pure endotoxin antagonist of high potency

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

OBSERVATIONS ON MODE OF ACTION OF ENDOTOXIN IN CHICK EMBRYOS

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

A lipid A analog, E5531, blocks the endotoxin response in human volunteers with experimental endotoxemia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Characterization of macrophage function in Mycobacterium lepraemurium-infected mice: sensitivity of mice to endotoxin and release of mediators and lysosomal enzymes after endotoxin treatment

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Structure and function of lipopolysaccharide binding protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The smallest known non-avian theropod dinosaur

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

TLR6: A novel member of an expanding toll-like receptor family

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-zeta in bacterial lipopolysaccharide-treated human monocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Soluble CD14 participates in the response of cells to lipopolysaccharide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Drosophila Toll and IL-1 receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The effects of hydrocortisone and estrogen on experimental fever induced by etiocholanolone

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

EFFECTS PRODUCED BY THE INTRAVENOUS INJECTION IN MAN OF A TOXIC ANTIGENIC MATERIAL DERIVED FROM EBERTHELLA TYPHOSA: CLINICAL, HEMATOLOGICAL, CHEMICAL AND SEROLOGICAL STUDIES.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Cutting edge: the toll pathway is required for resistance to gram-positive bacterial infections in Drosophila

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Cloning the interleukin 1 receptor from human T cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

A Toll-like receptor recognizes bacterial DNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Comparative studies on the toxicity of Escherichia coli lipopolysaccharide endotoxin in various animal species

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Role of the gut in multiple organ failure: bacterial translocation and permeability changes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Toll-like receptors: how they work and what they do.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

A family of human receptors structurally related to Drosophila Toll

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Some metabolic aspects of tolerance to bacterial endotoxin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Shock and tissue injury induced by recombinant human cachectin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

The evolution and genetics of innate immunity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.PHARMTOX.43.100901.135729

Identifiers

DOI

10.1146/ANNUREV.PHARMTOX.43.100901.135729

1 reference

6 August 2017

1 reference