(Q35056596)

25132557

6 August 2017

title

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma (English)

1 reference

6 August 2017

1 reference

4

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4 June 2020

author name string

Gareth R Howell

1

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4 June 2020

Katharine H MacNicoll

2

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4 June 2020

Catherine E Braine

3

1 reference

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4 June 2020

Danilo G Macalinao

5

1 reference

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4 June 2020

Gregory L Sousa

6

1 reference

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4 June 2020

Simon W M John

7

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4 June 2020

publication date

15 August 2014

1 reference

25132557

6 August 2017

published in

Neurobiology of Disease

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4 June 2020

volume

71

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4 June 2020

page(s)

44-52

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describes a project that uses

4 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4319373/fullTextXML

inferred from PubMed Central ID database lookup

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Endothelin B receptors contribute to retinal ganglion cell loss in a rat model of glaucoma

8 July 2018

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8 July 2018

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Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy

8 July 2018

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8 July 2018

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Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

8 July 2018

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8 July 2018

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A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

8 July 2018

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Cell Proliferation and Interleukin-6–Type Cytokine Signaling Are Implicated by Gene Expression Responses in Early Optic Nerve Head Injury in Rat Glaucoma

8 July 2018

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8 July 2018

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8 July 2018

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Molecular dissection of reactive astrogliosis and glial scar formation

8 July 2018

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Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist

8 July 2018

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Endothelin and its potential role in glaucoma

8 July 2018

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Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

8 July 2018

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The classical complement cascade mediates CNS synapse elimination

8 July 2018

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Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1

8 July 2018

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Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model

8 July 2018

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8 July 2018

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Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric

8 July 2018

1 reference

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Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma

8 July 2018

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Investigating the effect of ciliary body photodynamic therapy in a glaucoma mouse model

8 July 2018

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Intravitreal injection of endothelin-1 caused optic nerve damage following to ocular hypoperfusion in rabbits

8 July 2018

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8 July 2018

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Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration

8 July 2018

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Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

8 July 2018

1 reference

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High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development

8 July 2018

1 reference

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8 July 2018

1 reference

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Number of people with glaucoma worldwide

8 July 2018

1 reference

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Action of endothelin-1 on rat astrocytes through the ETB receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Cupping of the optic disc in ischemic optic neuropathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Failure of increased intracranial pressure to affect rapid axonal transport at the optic nerve head

8 July 2018

1 reference

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The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve

8 July 2018

1 reference

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Free calcium rise and mitogenesis in glial cells caused by endothelin.

8 July 2018

1 reference

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A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Optic nerve degeneration in the DBA/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Endothelin-1 modulates anterograde fast axonal transport in the central nervous system

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Endothelins regulate astrocyte gap junctions in rat hippocampal slices

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Effects of endothelin-1 on components of anterograde axonal transport in optic nerve.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1).

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

The role of intracellular calcium and protein kinase C in endothelin-stimulated proliferation of rat type I astrocytes.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Endothelins modulate dibutyryl cAMP-induced stellation of cultured astrocytes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

The astrocytic endothelin system: toward solving a mystery focus on "distinct pharmacological properties of ET-1 and ET-3 on astroglial gap junctions and Ca(2+) signaling"

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4319373

Intraocular pressure in inbred mouse strains

9 December 2018

1 reference

12 December 2020

Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport

1 reference

12 December 2020

Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray

1 reference

12 December 2020

Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve

1 reference

12 December 2020

Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve

1 reference

12 December 2020

Plasma and aqueous humor endothelin levels in primary open-angle glaucoma

1 reference

12 December 2020

10.1016/J.NBD.2014.07.016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25132557%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25132557%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

25132557

1 reference