(Q35058535)

6 August 2017

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title

Hide, shield and strike back: how HIV-infected cells avoid immune eradication (English)

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eradication of infectious diseases

6 August 2017

main subject

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B Matija Peterlin

1

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6 August 2017

Didier Trono

series ordinal

2

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6 August 2017

language of work or name

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1 February 2003

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Nature Reviews Immunology

6 August 2017

published in

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6 August 2017

volume

3

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6 August 2017

issue

2

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6 August 2017

page(s)

97-107

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The challenge of viral reservoirs in HIV-1 infection

6 August 2017

cites work

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Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection

31 March 2020

1 reference

1918 Spanish influenza: the secrets remain elusive

31 March 2020

1 reference

Viral persistence: mechanisms and consequences

31 March 2020

1 reference

Viral strategies of immune evasion

31 March 2020

1 reference

Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

31 March 2020

1 reference

Lentivirus replication and regulation

31 March 2020

1 reference

HIV-1: fifteen proteins and an RNA

31 March 2020

1 reference

The plasma membrane as a combat zone in the HIV battlefield

31 March 2020

1 reference

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

31 March 2020

1 reference

DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection

31 March 2020

1 reference

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

31 March 2020

1 reference

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

31 March 2020

1 reference

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

31 March 2020

1 reference

The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation

31 March 2020

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HIV-1 integration in the human genome favors active genes and local hotspots

31 March 2020

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HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

31 March 2020

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Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication

31 March 2020

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Molecular basis of cell cycle dependent HIV-1 replication. Implications for control of virus burden.

31 March 2020

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Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes

31 March 2020

1 reference

Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes

31 March 2020

1 reference

Control of RNA initiation and elongation at the HIV-1 promoter

31 March 2020

1 reference

Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation

31 March 2020

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Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

31 March 2020

1 reference

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

31 March 2020

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P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

31 March 2020

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Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

31 March 2020

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NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.

31 March 2020

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Retroviruses as model systems for the study of nuclear RNA export pathways

31 March 2020

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Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts

31 March 2020

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A role for ubiquitin ligase recruitment in retrovirus release

31 March 2020

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Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

31 March 2020

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HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

31 March 2020

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Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)

31 March 2020

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Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation

31 March 2020

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Nef increases infectivity of HIV via lipid rafts

31 March 2020

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Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

31 March 2020

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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

31 March 2020

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Viral dynamics in human immunodeficiency virus type 1 infection

31 March 2020

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The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4

31 March 2020

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A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency

31 March 2020

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Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1

31 March 2020

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Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts

31 March 2020

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

31 March 2020

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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

31 March 2020

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Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

31 March 2020

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Control of homeostasis of CD8+ memory T cells by opposing cytokines.

31 March 2020

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31 March 2020

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Persistence of HIV-1 Transcription in Peripheral-Blood Mononuclear Cells in Patients Receiving Potent Antiretroviral Therapy

31 March 2020

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The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy.

31 March 2020

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Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy

31 March 2020

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Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis

31 March 2020

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Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections

31 March 2020

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

31 March 2020

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The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

31 March 2020

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CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA

31 March 2020

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Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter

31 March 2020

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Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome

31 March 2020

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DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

31 March 2020

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NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

31 March 2020

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Domains in the SPT5 protein that modulate its transcriptional regulatory properties

31 March 2020

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Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.

31 March 2020

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Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation

31 March 2020

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Tat-SF1 protein associates with RAP30 and human SPT5 proteins

31 March 2020

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Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.

31 March 2020

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Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency

31 March 2020

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The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals

31 March 2020

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

31 March 2020

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

31 March 2020

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Putting together an MHC class I molecule

31 March 2020

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A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

31 March 2020

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Viral subversion of the immune system

31 March 2020

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HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway

31 March 2020

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Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

31 March 2020

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Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

31 March 2020

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A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

31 March 2020

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

31 March 2020

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Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

31 March 2020

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Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

31 March 2020

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HIV Tat represses transcription of the beta 2-microglobulin promoter

31 March 2020

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The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

31 March 2020

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Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

31 March 2020

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PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

31 March 2020

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

31 March 2020

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Inhibition of calcium-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by wortmannin

31 March 2020

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PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization

31 March 2020

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HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway

31 March 2020

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The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

31 March 2020

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Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

31 March 2020

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Repression of MHC class I gene promoter activity by two-exon Tat of HIV

31 March 2020

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HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes

31 March 2020

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Effects of HIV-1 Tat on expression of HLA class I molecules

31 March 2020

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Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

31 March 2020

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Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

31 March 2020

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Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

31 March 2020

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Skewed maturation of memory HIV-specific CD8 T lymphocytes

31 March 2020

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Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

31 March 2020

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Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.

31 March 2020

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HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

31 March 2020

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HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

31 March 2020

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Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules

31 March 2020

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Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

31 March 2020

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Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia

31 March 2020

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HIV preferentially infects HIV-specific CD4+ T cells

31 March 2020

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Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection

31 March 2020

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Regulation of class II expression in monocytic cells after HIV-1 infection

31 March 2020

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Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1.

31 March 2020

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Structured treatment interruptions as a potential alternative therapeutic regimen for HIV-infected patients: a review of recent clinical data and future prospects

31 March 2020

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Structured treatment interruptions in antiretroviral management of HIV-1.

31 March 2020

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Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection

31 March 2020

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Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

31 March 2020

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Reduction of the HIV-1-infected T-cell reservoir by immune activation treatment is dose-dependent and restricted by the potency of antiretroviral drugs.

31 March 2020

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Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy

31 March 2020

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Prospects for vaccine protection against HIV-1 infection and AIDS.

31 March 2020

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HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

31 March 2020

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Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.

31 March 2020

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Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level

31 March 2020

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Modulation of HIV-1 replication by RNA interference

31 March 2020

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Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

31 March 2020

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siRNA-directed inhibition of HIV-1 infection

31 March 2020

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Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

31 March 2020

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7 January 2021

Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells

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7 January 2021

Nonproductive human immunodeficiency virus type 1 infection in nucleoside-treated G0 lymphocytes

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7 January 2021

Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line

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7 January 2021

Identifiers

DOI

10.1038/NRI998

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Dimensions Publication ID

6 August 2017

1023316100

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