(Q35059112)

6 August 2017

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title

Chemical proteomics and its application to drug discovery. (English)

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6 August 2017

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2

Matthew Bogyo

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6 August 2017

Douglas A Jeffery

1

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6 August 2017

publication date

1 February 2003

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Current Opinion in Biotechnology

6 August 2017

published in

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6 August 2017

volume

14

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6 August 2017

issue

1

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6 August 2017

page(s)

87-95

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Drug discovery of the future: the implications of the human genome project

6 August 2017

cites work

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The Sequence of the Human Genome

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Applied genomics: integration of the technology within pharmaceutical research and development

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7 January 2021

Structural proteomics: developments in structure-to-function predictions

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7 January 2021

Proteomics to study genes and genomes

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7 January 2021

Chemical strategies for the global analysis of protein function

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7 January 2021

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

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7 January 2021

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

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7 January 2021

Activity-based protein profiling: the serine hydrolases

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Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

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Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

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7 January 2021

Chemical arrows for enzymatic targets

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7 January 2021

Suicide substrates, mechanism-based enzyme inactivators: recent developments

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7 January 2021

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

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7 January 2021

Direct screening for phosphatase activity by turnover-based capture of protein catalysts

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7 January 2021

Suicide inactivation of human prostatic acid phosphatase and a phosphotyrosine phosphatase

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7 January 2021

Chemical selection for catalysis in combinatorial antibody libraries

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7 January 2021

Affinity labeling of purine nucleotide sites in proteins

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7 January 2021

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

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7 January 2021

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

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7 January 2021

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

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7 January 2021

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

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7 January 2021

Chemical approaches for functionally probing the proteome

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7 January 2021

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

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7 January 2021

What does it mean to identify a protein in proteomics?

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7 January 2021

Mass spectrometry and proteomics

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7 January 2021

Introduction to avidin-biotin technology

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7 January 2021

Quantitative proteome analysis by solid-phase isotope tagging and mass spectrometry

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7 January 2021

Drug discovery--an operating model for a new era

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7 January 2021

Defining a link between gap junction communication, proteolysis, and cataract formation

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7 January 2021

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

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7 January 2021

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

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7 January 2021

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7 January 2021

Drug discovery: a historical perspective

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7 January 2021

Profiling serine hydrolase activities in complex proteomes

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7 January 2021

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies

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7 January 2021

Protein kinases--the major drug targets of the twenty-first century?

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7 January 2021

ATP site-directed competitive and irreversible inhibitors of protein kinases

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7 January 2021

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

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7 January 2021

Protein tyrosine phosphatases

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7 January 2021

Protein tyrosine phosphatases: mechanisms of catalysis and regulation

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7 January 2021

10.1016/S0958-1669(02)00010-1

Identifiers

DOI

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6 August 2017

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