(Q35062604)

6 August 2017

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title

Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury (English)

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6 August 2017

0 references

1 reference

Alma Siflinger-Birnboim

series ordinal

1

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6 August 2017

Arnold Johnson

series ordinal

2

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6 August 2017

publication date

1 March 2003

1 reference

American Journal of Physiology - Lung Cellular and Molecular Physiology

6 August 2017

published in

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6 August 2017

volume

284

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6 August 2017

issue

3

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6 August 2017

page(s)

L435-51

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Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby acti

6 August 2017

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Bradykinin- and thrombin-induced increases in endothelial permeability occur independently of phospholipase C but require protein kinase C activation

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Protein kinase C isoforms as therapeutic targets in nervous system disease states

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Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

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H2O2 and genistein differentially modulate protein tyrosine phosphorylation, endothelial morphology, and monolayer barrier function

21 January 2018

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Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer

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Membrane targeting by C1 and C2 domains

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Protective effect of lipophilic antioxidants on phorbol-induced acute lung injury in rats

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Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

21 January 2018

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Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C

21 January 2018

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Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst

21 January 2018

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

21 January 2018

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Thrombin's enzymatic activity increases permeability of endothelial cell monolayers

21 January 2018

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Protein kinase C isozymes and the regulation of diverse cell responses

21 January 2018

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Free radicals in the physiological control of cell function

21 January 2018

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Calpain-induced downregulation of activated protein kinase C-alpha affects lung epithelial cell morphology

21 January 2018

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Clinical developments for treating ARDS.

21 January 2018

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Vascular recruitment increases evidence of lung injury.

21 January 2018

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The role of the calpain-calpastatin system in thyrotropin-releasing hormone-induced selective down-regulation of a protein kinase C isozyme, nPKC epsilon, in rat pituitary GH4C1 cells

21 January 2018

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Role of endothelin-1 in lung disease

21 January 2018

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Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Transcriptional mechanisms of acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Thrombin and antithrombotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Endothelial barrier dysfunction and p42 oxidation induced by TNF-alpha are mediated by nitric oxide.

21 January 2018

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Tumor necrosis factor-alpha alters pulmonary vasoreactivity via neutrophil-derived oxidants

21 January 2018

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Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

TNFalpha activates c-Jun amino terminal kinase through p47(phox).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Modulation of arterial endothelial permeability: studies on an in vitro model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Role of interstitium in clearance of alveolar fluid in normal and injured lungs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Tumour necrosis factor-alpha induces superoxide anion generation in mitochondria of L929 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Mechanisms of pulmonary edema induced by tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Antioxidants may contribute in the fight against ageing: an in vitro model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

PMA-induced pulmonary edema: mechanisms of the vasoactive response.

21 January 2018

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Nitrovasodilator repletion increases TNF-alpha-induced pulmonary edema

21 January 2018

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Effects of different-size microemboli on lung fluid and protein exchange

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase inhibitor prevents pulmonary edema in response to H2O2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Human recombinant tumor necrosis factor alpha infusion mimics endotoxemia in awake sheep

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Role of cadherin internalization in hydrogen peroxide-mediated endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

H(2)O(2)-mediated permeability II: importance of tyrosine phosphatase and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

The role of p38 MAP kinase in hydrogen peroxide mediated endothelial solute permeability.

21 January 2018

1 reference

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Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Neutrophil activation and acute lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Calcium dependence of the thrombin-induced increase in endothelial albumin permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Oxidant stress and endothelial cell dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Increased endothelial albumin permeability mediated by protein kinase C activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Cellular and humoral mediators of pulmonary edema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Culturing endothelial cells of microvascular origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Plasma tumor necrosis factor in patients with septic shock. Mortality rate, incidence of adult respiratory distress syndrome, and effects of methylprednisolone administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Early pulmonary endothelial enzyme dysfunction after phorbol ester in conscious rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Lung morphological and permeability changes induced by intravascular coagulation in dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase C beta 1 overexpression augments phorbol ester-induced increase in endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

A transmembrane tight junction protein selectively expressed on endothelial cells and platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Regulation of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Involvement of protein kinase C in superoxide anion-induced activation of nuclear factor-kappa B in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

The complete primary structure of protein kinase C--the major phorbol ester receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Transcriptional regulation of tissue factor expression in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Update on pulmonary edema: the role and regulation of endothelial barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Phorbol myristate acetate-induced injury of isolated perfused rat lungs: neutrophil dependence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Effects of phorbol myristate acetate-stimulated human leukocytes on rat lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Reactive oxygen species as intracellular messengers during cell growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Adaptor proteins in protein kinase C-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Hemodynamic and cardiovascular effects of nitric oxide modulation in the therapy of septic shock

21 January 2018

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The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Activation of protein kinase C mediates altered pulmonary vasoreactivity induced by tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Molecular sieving characteristics of the cultured endothelial monolayer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Neutrophil adhesion to endothelial cells impairs the effects of catalase and glutathione in preventing endothelial injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Regulation of PKC alpha activity by C1-C2 domain interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Protein kinase C phosphorylates caldesmon77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Capillary fluid filtration. Starling forces and lymph flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Synergistic effects of tumor necrosis factor-alpha and thrombin in increasing endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Nitric oxide in septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Cachetin/TNF-alpha in septic shock and septic adult respiratory distress syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Pathophysiology and implications for treatment of acute respiratory distress syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Regulation of surfactant proteins by LPS and proinflammatory cytokines in fetal and newborn lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Complement and contact activation related to surfactant response in respiratory distress syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Identification of PKC-isoform-specific biological actions using pharmacological approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Redox regulation of endothelial barrier integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Hydrogen peroxide-induced cytoskeletal rearrangement in cultured pulmonary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Endothelial cell interactions with granulocytes: tethering and signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

Redox regulation of fos and jun DNA-binding activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

The role of protein kinase C in cell surface signal transduction and tumour promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00106.2002

10.1152/AJPLUNG.00106.2002

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference