(Q35073617)

English

Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes

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scholarly article

1 reference

Europe PubMed Central

6 August 2017

Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes (English)

1 reference

Europe PubMed Central

6 August 2017

author name string

Ji Miao

1

1 reference

Europe PubMed Central

6 August 2017

Sung-E Choi

2

1 reference

Europe PubMed Central

6 August 2017

Sun Mi Seok

3

1 reference

Europe PubMed Central

6 August 2017

Linda Yang

4

1 reference

Europe PubMed Central

6 August 2017

William J Zuercher

5

1 reference

Europe PubMed Central

6 August 2017

Yong Xu

6

1 reference

Europe PubMed Central

6 August 2017

Timothy M Willson

7

1 reference

Europe PubMed Central

6 August 2017

H Eric Xu

8

1 reference

Europe PubMed Central

6 August 2017

Jongsook Kim Kemper

9

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Europe PubMed Central

6 August 2017

publication date

12 May 2011

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Europe PubMed Central

6 August 2017

Molecular Endocrinology

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Europe PubMed Central

6 August 2017

25

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Europe PubMed Central

6 August 2017

7

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Europe PubMed Central

6 August 2017

1159-1169

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Europe PubMed Central

6 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3125094/fullTextXML

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Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner

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Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis

1 reference

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SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis

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Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation

1 reference

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The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP.

1 reference

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Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor

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Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis

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Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis

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Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression

1 reference

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Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.

1 reference

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Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism

1 reference

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Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells

1 reference

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Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

1 reference

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Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression

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Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

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Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding

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Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

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Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

1 reference

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

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LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

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p38 MAP kinase: a convergence point in cancer therapy

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Retinoid targets for apoptosis induction

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

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Does loss of bile acid homeostasis make mice melancholy?

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Bile acid regulation of gene expression: roles of nuclear hormone receptors.

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Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner

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Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

1 reference

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

1 reference

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1 reference

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Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes

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A sharper image of SHP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3125094

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Redundant pathways for negative feedback regulation of bile acid production

1 reference

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Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

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Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21566081

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/ME.2011-0033

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

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