(Q35073617)

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Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes

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Europe PubMed Central

PubMed publication ID

6 August 2017

Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

Ji Miao

1

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6 August 2017

Sung-E Choi

2

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6 August 2017

Sun Mi Seok

3

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6 August 2017

Linda Yang

4

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6 August 2017

William J Zuercher

5

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6 August 2017

Yong Xu

6

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6 August 2017

Timothy M Willson

7

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6 August 2017

H Eric Xu

8

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6 August 2017

Jongsook Kim Kemper

9

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6 August 2017

publication date

12 May 2011

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6 August 2017

Molecular Endocrinology

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6 August 2017

25

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6 August 2017

7

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Europe PubMed Central

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6 August 2017

1159-1169

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PubMed publication ID

6 August 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3125094/fullTextXML

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SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis

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Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation

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The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP.

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Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis

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Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression

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Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.

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Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism

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Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells

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Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding

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Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

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Retinoid targets for apoptosis induction

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Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

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A sharper image of SHP.

1 reference

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12 December 2020

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Identifiers

10.1210/ME.2011-0033

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Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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