(Q35074280)

6 August 2017

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title

Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate (English)

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6 August 2017

3

Lars Rönnbäck

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6 August 2017

4

Elisabeth Hansson

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6 August 2017

2

Elinor Ben-Menachem

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6 August 2017

Mikael Angehagen

1

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6 August 2017

publication date

1 February 2003

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6 August 2017

published in

Neurochemical Research

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6 August 2017

volume

28

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6 August 2017

issue

2

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6 August 2017

page(s)

333-340

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Biochemical and clinical effects of gamma-vinyl GABA in patients with epilepsy

6 August 2017

cites work

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12 December 2020

The new antiepileptic drugs: a systematic review of their efficacy and tolerability

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12 December 2020

Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired

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12 December 2020

The neurobiology of slow synaptic transmission

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12 December 2020

Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors

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12 December 2020

Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs

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12 December 2020

gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

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12 December 2020

Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy

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12 December 2020

Somatostatin, beta-endorphin, and prolactin levels in human cerebrospinal fluid during the gamma-vinyl-GABA treatment of patients with complex partial epilepsy

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12 December 2020

Topiramate as an inhibitor of carbonic anhydrase isoenzymes

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12 December 2020

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

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12 December 2020

In vitro ischemia promotes glutamate-mediated free radical generation and intracellular calcium accumulation in hippocampal pyramidal neurons.

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12 December 2020

Effect of long-term vigabatrin therapy on selected neurotransmitter concentrations in cerebrospinal fluid

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12 December 2020

Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies

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12 December 2020

The effect of vigabatrin (gamma-vinyl GABA) on cerebral blood flow and metabolism

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12 December 2020

Functionally relevant and functionally disruptive (epileptic) synchronized oscillations in brain slices

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12 December 2020

GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.

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12 December 2020

Differential sensitivity of recombinant GABA(A) receptors expressed in Xenopus oocytes to modulation by topiramate

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12 December 2020

Recent advances in the diagnosis and treatment of epilepsy

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12 December 2020

The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function

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12 December 2020

Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, ?-acetylenic GABA (4-amino-hex-5-ynoic acid) and ?-vinyl GABA (4-amino-hex-5-enoic acid)

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12 December 2020

Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold.

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12 December 2020

Inhibition of forskolin-activated adenylate cyclase by ethanol and other solvents

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12 December 2020

Pharmacology and clinical pharmacology of vigabatrin.

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12 December 2020

Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

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12 December 2020

Evidence for synaptic apoptosis

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12 December 2020

The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients

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12 December 2020

Effect of long-term vigabatrin therapy on GABA and other amino acid concentrations in the central nervous system--a case study

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12 December 2020

Vigabatrin aggravates absences and absence status

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12 December 2020

Kainate, a double agent that generates seizures: two decades of progress

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12 December 2020

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

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12 December 2020

Early identification of refractory epilepsy

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12 December 2020

A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Topiramate YL Study Group

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12 December 2020

Molecular mechanisms of calcium-dependent excitotoxicity

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12 December 2020

Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid)

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12 December 2020

Activity of thalamic reticular neurons during spontaneous genetically determined spike and wave discharges.

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12 December 2020

Attempts to Correlate Alterations in Brain GABA Metabolism by GABA-T Inhibitors with Their Anticonvulsant Effects

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12 December 2020

Nonfocal generalized tonic-clonic seizures: response during long-term topiramate treatment. Topiramate YTC/YTCE Study Group.

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12 December 2020

Two new actions of topiramate: inhibition of depolarizing GABA(A)-mediated responses and activation of a potassium conductance.

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12 December 2020

Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.

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12 December 2020

Glutamate transport and metabolism in astrocytes.

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12 December 2020

Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy

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12 December 2020

Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.

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12 December 2020

Topiramate: preclinical evaluation of structurally novel anticonvulsant.

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12 December 2020

Clinical pharmacology and therapeutic use of the new antiepileptic drugs

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12 December 2020

On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat

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12 December 2020

Free radical production correlates with cell death in an in vitro model of epilepsy

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12 December 2020

Occlusion and metabolism of gamma-aminobutyric acid by brain tissue.

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12 December 2020

Double-blind dose reduction study of vigabatrin in complex partial epilepsy.

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12 December 2020

Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system

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12 December 2020

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12 December 2020

Characterization of the metabotropic glutamate receptors (mGluRs) which modulate GABA-mediated inhibition in the ventrobasal thalamus

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12 December 2020

Enhanced neuroprotection and reduced hemorrhagic incidence in focal cerebral ischemia of rat by low dose combination therapy of urokinase and topiramate

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12 December 2020

Importance of specifying the type of epilepsy

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12 December 2020

Cellular actions of topiramate: blockade of kainate-evoked inward currents in cultured hippocampal neurons

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12 December 2020

c-JUN expression and apoptotic cell death in kainate-induced temporal lobe epilepsy

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12 December 2020

Metabolic manipulation of neural tissue to counter the hypersynchronous excitation of migraine and epilepsy

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12 December 2020

Initial observations on effect of vigabatrin on in vivo 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain

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12 December 2020

Tiagabine-induced absence status in idiopathic generalized epilepsy

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12 December 2020

Long-term safety of tiagabine

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12 December 2020

Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase.

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12 December 2020

Enhancement of spike and wave discharges by microinjection of bicuculline into the reticular nucleus of rats with absence epilepsy

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12 December 2020

Identifiers

DOI

10.1023/A:1022393604014

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Dimensions Publication ID

6 August 2017

1033771850

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