(Q35075551)

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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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author name string

Ruth F Sommese

1

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Europe PubMed Central

PubMed publication ID

6 August 2017

Suman Nag

2

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Europe PubMed Central

PubMed publication ID

6 August 2017

Shirley Sutton

3

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Europe PubMed Central

PubMed publication ID

6 August 2017

Susan M Miller

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

James A Spudich

5

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Europe PubMed Central

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6 August 2017

Kathleen M Ruppel

6

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6 August 2017

language of work or name

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publication date

18 December 2013

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Europe PubMed Central

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6 August 2017

8

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Europe PubMed Central

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6 August 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

e83403

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

copyright license

Creative Commons Attribution 4.0 International

18 December 2013

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April 2022 Public Data File from Crossref

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0 references

Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

1 reference

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8 July 2018

Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors.

1 reference

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8 July 2018

Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy

1 reference

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8 July 2018

Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.

1 reference

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8 July 2018

Genetic testing for dilated cardiomyopathy in clinical practice

1 reference

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8 July 2018

The cell biology of disease: cellular mechanisms of cardiomyopathy.

1 reference

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8 July 2018

A model of calcium activation of the cardiac thin filament

1 reference

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8 July 2018

Tracking single particles and elongated filaments with nanometer precision

1 reference

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8 July 2018

Thin filament mutations: developing an integrative approach to a complex disorder

1 reference

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8 July 2018

Targeted amino-terminal acetylation of recombinant proteins in E. coli

1 reference

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8 July 2018

Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Effects of actin-myosin kinetics on the calcium sensitivity of regulated thin filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Insights into human beta-cardiac myosin function from single molecule and single cell studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Sarcomere control mechanisms and the dynamics of the cardiac cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

The genetics of dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Functional diversity among a family of human skeletal muscle myosin motors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Kinetics of cardiac sarcomeric processes and rate-limiting steps in contraction and relaxation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

A peptide tag system for facile purification and single-molecule immobilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Kinetic and equilibrium analysis of the myosin ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Tropomyosin: function follows structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Hypertrophic cardiomyopathy: etiology, diagnosis, and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Calcium, thin filaments, and the integrative biology of cardiac contractility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Myosin crossbridge activation of cardiac thin filaments: implications for myocardial function in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Chaperone-mediated folding and assembly of myosin in striated muscle

1 reference

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8 July 2018

Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

It takes "heart" to win: what makes the heart powerful?

1 reference

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8 July 2018

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Regulation of contraction in striated muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Calcium regulation of thin filament movement in an in vitro motility assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Functional alpha-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Evidence for a force-dependent component of calcium binding to cardiac troponin C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Two-site attachment of troponin to pyrene-labeled tropomyosin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Two genetically expressed troponin T fragments representing alpha and beta isoforms exhibit functional differences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Isolation, expression, and mutation of a rabbit skeletal muscle cDNA clone for troponin I. The role of the NH2 terminus of fast skeletal muscle troponin I in its biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

N-(1-Pyrene)maleimide: a fluorescent crosslinking reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

8 July 2018

Expanding the range of free calcium regulation in biological solutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

27 September 2018

F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

27 September 2018

Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

27 September 2018

Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3867432

27 September 2018

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of Diastolic Function With Doppler Tissue Imaging to Predict Genotype in Preclinical Hypertrophic Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different functional properties of troponin T mutants that cause dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The excimer fluorescence of pyrene-labeled tropomyosin. A probe of conformational dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of muscle actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

21 Preparation and identification of α- and β-tropomyosins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorescence studies of the conformation of pyrene-labeled tropomyosin: effects of F-actin and myosin subfragment 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro motility analysis of actin-tropomyosin regulation by troponin and calcium. The thin filament is switched as a single cooperative unit

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the four Ca2+ binding sites of troponin C in the regulation of skeletal muscle contraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spectrum and clinical significance of systolic function and myocardial fibrosis assessed by cardiovascular magnetic resonance in hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24367593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0083403

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

2013PLoSO...883403S

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

ResearchGate publication ID

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