(Q35076795)

English

Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

scientific article

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scholarly article

1 reference

Europe PubMed Central

6 August 2017

Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response (English)

1 reference

Europe PubMed Central

6 August 2017

Transmembrane serine protease 2

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betacoronaviruses spike protein

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spike glycoprotein [SARS-Cov]

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based on heuristic

inferred from abstract

1 reference

based on heuristic

inferred from title

severe acute respiratory syndrome

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based on heuristic

inferred from title

Stefan Pöhlmann

14

object named as

Stefan Pöhlmann

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Susanne Pfefferle

6

object named as

Susanne Pfefferle

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1

object named as

Ilona Glowacka

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10

object named as

Kerstin Gnirss

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Theodros Solomon Tsegaye

object named as

Theodros Solomon Tsegaye

8

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Marcel Alexander Müller

object named as

Marcel A Müller

3

0 references

Christian Drosten

13

object named as

Christian Drosten

1 reference

Europe PubMed Central

6 August 2017

Stephanie Stanelle-Bertram

2

object named as

Stephanie Bertram

1 reference

Europe PubMed Central

6 August 2017

Daniela Niemeyer

11

object named as

Daniela Niemeyer

1 reference

Europe PubMed Central

6 August 2017

author name string

Paul Allen

4

1 reference

Europe PubMed Central

6 August 2017

Elizabeth Soilleux

5

1 reference

Europe PubMed Central

6 August 2017

Imke Steffen

7

1 reference

Europe PubMed Central

6 August 2017

Yuxian He

9

1 reference

Europe PubMed Central

6 August 2017

Heike Schneider

12

1 reference

Europe PubMed Central

6 August 2017

language of work or name

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publication date

16 February 2011

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Europe PubMed Central

6 August 2017

Journal of Virology

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Europe PubMed Central

6 August 2017

85

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Europe PubMed Central

6 August 2017

4122-4134

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Europe PubMed Central

6 August 2017

9

1 reference

Europe PubMed Central

6 August 2017

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Novel insights into proteolytic cleavage of influenza virus hemagglutinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Type II transmembrane serine proteases in cancer and viral infections.

1 reference

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8 July 2018

Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Proteolytic activation of the 1918 influenza virus hemagglutinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Entry from the cell surface of severe acute respiratory syndrome coronavirus with cleaved S protein as revealed by pseudotype virus bearing cleaved S protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

The cytoplasmic tail of the severe acute respiratory syndrome coronavirus spike protein contains a novel endoplasmic reticulum retrieval signal that binds COPI and promotes interaction with membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Antigenic and immunogenic characterization of recombinant baculovirus-expressed severe acute respiratory syndrome coronavirus spike protein: implication for vaccine design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Phenotypic analysis of mice lacking the Tmprss2-encoded protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Bats are natural reservoirs of SARS-like coronaviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

1 reference

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8 July 2018

Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.

1 reference

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8 July 2018

Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine

1 reference

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8 July 2018

The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells

1 reference

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8 July 2018

Cellular entry of the SARS coronavirus

1 reference

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8 July 2018

Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression

1 reference

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8 July 2018

Cleavage and serum reactivity of the severe acute respiratory syndrome coronavirus spike protein

1 reference

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8 July 2018

Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor

1 reference

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8 July 2018

S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients

1 reference

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8 July 2018

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.

1 reference

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8 July 2018

pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN

1 reference

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Ectodomain shedding of the glycoprotein GP of Ebola virus

1 reference

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8 July 2018

Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor

1 reference

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8 July 2018

Serology of severe acute respiratory syndrome: implications for surveillance and outcome

1 reference

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8 July 2018

A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice

1 reference

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8 July 2018

Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry

1 reference

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8 July 2018

Expression cloning of functional receptor used by SARS coronavirus

1 reference

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8 July 2018

Guideline to reference gene selection for quantitative real-time PCR

1 reference

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8 July 2018

A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China

1 reference

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8 July 2018

DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Mechanisms of viral membrane fusion and its inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

8 July 2018

Understanding influenza virus pathogenicity

1 reference

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8 July 2018

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

1 reference

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The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma

1 reference

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27 September 2018

Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry.

1 reference

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Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies.

1 reference

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27 September 2018

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

1 reference

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27 September 2018

Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccines.

1 reference

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27 September 2018

Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases.

1 reference

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27 September 2018

The SARS-CoV S glycoprotein: expression and functional characterization.

1 reference

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27 September 2018

Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice.

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27 September 2018

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.

1 reference

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27 September 2018

Lung pathology of fatal severe acute respiratory syndrome.

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27 September 2018

Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors

1 reference

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27 September 2018

Severe acute respiratory syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3126222

27 September 2018

The intracellular sites of early replication and budding of SARS-coronavirus

1 reference

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16 November 2018

Identifiers

10.1128/JVI.02232-10

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

ResearchGate publication ID

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