(Q35078148)

6 August 2017

title

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor (English)

1 reference

6 August 2017

Sarah A Nickolls

1

1 reference

6 August 2017

Sian Humphreys

series ordinal

2

1 reference

6 August 2017

Mellissa Clark

series ordinal

3

1 reference

6 August 2017

Gordon McMurray

series ordinal

4

1 reference

6 August 2017

language of work or name

English

0 references

publication date

20 December 2013

1 reference

6 August 2017

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6 August 2017

volume

8

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6 August 2017

issue

12

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6 August 2017

page(s)

e83691

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Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

20 December 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure.

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8 July 2018

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A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

8 July 2018

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Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells

8 July 2018

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Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor

8 July 2018

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Endomorphin-2: a biased agonist at the μ-opioid receptor.

8 July 2018

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GRK2: multiple roles beyond G protein-coupled receptor desensitization

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Understanding the effect of different assay formats on agonist parameters: a study using the µ-opioid receptor

8 July 2018

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

8 July 2018

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Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons

8 July 2018

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Beta-arrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation.

8 July 2018

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The influence of G protein subtype on agonist action at D2 dopamine receptors

8 July 2018

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Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence

8 July 2018

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

8 July 2018

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

8 July 2018

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Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Arresting developments in heptahelical receptor signaling and regulation

8 July 2018

1 reference

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Enhanced morphine analgesia in mice lacking beta-arrestin 2

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Morphine-activated opioid receptors elude desensitization by beta-arrestin

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Determination of the amino acid residue involved in [3H]beta-funaltrexamine covalent binding in the cloned rat mu-opioid receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Operational models of pharmacological agonism.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Minimum-structure enkephalin analogues incorporating L-tyrosine, D(or L)-phenylalanine, and a diamine spacer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Morphine side effects in beta-arrestin 2 knockout mice

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0083691

Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0083691

Beta-arrestin2 as a competitor for GRK2 interaction with the GLP-1 receptor upon receptor activation.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0083691

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3869807

10.1371/JOURNAL.PONE.0083691

27 September 2018

Identifiers

DOI

1 reference

6 August 2017

0 references

1 reference

6 August 2017

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