(Q35078578)

25505253

6 August 2017

title

PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer (English)

1 reference

6 August 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Miika Ahdesmaki

10

1 reference

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11 June 2020

author name string

Jie Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Riet van der Meer

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Philip D Anderson

4

1 reference

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11 June 2020

Omar E Franco-Coronel

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Max H Kushner

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Joel H Everett

7

1 reference

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11 June 2020

Omar Hameed

8

1 reference

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11 June 2020

Erika K Keeton

9

1 reference

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11 June 2020

Shaun E Grosskurth

11

1 reference

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11 June 2020

Dennis Huszar

12

1 reference

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11 June 2020

Sarki A Abdulkadir

13

1 reference

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11 June 2020

language of work or name

English

0 references

publication date

13 December 2014

1 reference

25505253

Journal of the National Cancer Institute

6 August 2017

published in

1 reference

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11 June 2020

volume

107

1 reference

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11 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

cites work

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AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

8 July 2018

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8 July 2018

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8 July 2018

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Why target PIM1 for cancer diagnosis and treatment?

8 July 2018

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8 July 2018

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Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

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Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

8 July 2018

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Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer

8 July 2018

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Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation

8 July 2018

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Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma

8 July 2018

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Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.

8 July 2018

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Pim kinase-dependent inhibition of c-Myc degradation

8 July 2018

1 reference

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Wild-type p53 and p73 negatively regulate expression of proliferation related genes

8 July 2018

1 reference

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

8 July 2018

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Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor

8 July 2018

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Context-dependent hormone-refractory progression revealed through characterization of a novel murine prostate cancer cell line.

8 July 2018

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Pim family kinases enhance tumor growth of prostate cancer cells

8 July 2018

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Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis

8 July 2018

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Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line.

8 July 2018

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An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

8 July 2018

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8 July 2018

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

8 July 2018

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8 July 2018

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8 July 2018

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PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases.

27 September 2018

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PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

27 September 2018

1 reference

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Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.

27 September 2018

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Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis

27 September 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

27 September 2018

1 reference

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Myc-driven murine prostate cancer shares molecular features with human prostate tumors

27 September 2018

1 reference

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Hypoxic prostate/muscle PO2 ratio predicts for outcome in patients with localized prostate cancer: long-term results

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25505253

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/JNCI/DJU407

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505253%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

25505253

1 reference