(Q37820056)

23 August 2017

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title

For better or for worse: the role of Pim oncogenes in tumorigenesis (English)

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23 August 2017

Martijn C Nawijn

1

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23 August 2017

Andrej Alendar

series ordinal

2

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23 August 2017

Anton Berns

series ordinal

3

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23 August 2017

language of work or name

English

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publication date

9 December 2010

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23 August 2017

Nature Reviews Cancer

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23 August 2017

11

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23 August 2017

23-34

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23 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrc2986

23 August 2017

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cites work

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally

1 reference

CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-kappa B pathway

21 January 2018

1 reference

Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.

21 January 2018

1 reference

Pim3 negatively regulates glucose-stimulated insulin secretion

21 January 2018

1 reference

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

21 January 2018

1 reference

The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases.

31 March 2020

1 reference

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

31 March 2020

1 reference

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

31 March 2020

1 reference

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

31 March 2020

1 reference

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase

31 March 2020

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In vivo analysis of Pim-1 deficiency

31 March 2020

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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

31 March 2020

1 reference

KID-1, a protein kinase induced by depolarization in brain

31 March 2020

1 reference

Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.

31 March 2020

1 reference

Role of pim-1 in smooth muscle cell proliferation

31 March 2020

1 reference

Pim-1 regulates cardiomyocyte survival downstream of Akt.

31 March 2020

1 reference

Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro.

31 March 2020

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Differentiation-associated expression of the proto-oncogene pim-1 in cultured human keratinocytes

31 March 2020

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Pim-1 kinase expression during murine mammary development

31 March 2020

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Pim-1 levels determine the size of early B lymphoid compartments in bone marrow

31 March 2020

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Cardiac progenitor cell cycling stimulated by pim-1 kinase

31 March 2020

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Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases Pim-1 and Pim-3

31 March 2020

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Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

31 March 2020

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Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels

31 March 2020

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Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition

31 March 2020

1 reference

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

31 March 2020

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Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

31 March 2020

1 reference

Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells

31 March 2020

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eIF-4E expression and its role in malignancies and metastases.

31 March 2020

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eIF4E is a central node of an RNA regulon that governs cellular proliferation

31 March 2020

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The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway

31 March 2020

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Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death

31 March 2020

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The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs

31 March 2020

1 reference

Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1

31 March 2020

1 reference

miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts

31 March 2020

1 reference

Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells

31 March 2020

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Structure and substrate specificity of the Pim-1 kinase

31 March 2020

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Protein phosphatase 2A regulates the stability of Pim protein kinases

31 March 2020

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Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.

31 March 2020

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Regulation of Pim-1 by Hsp90

31 March 2020

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Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway

31 March 2020

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Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation

31 March 2020

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Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

31 March 2020

1 reference

The Pim kinases control rapamycin-resistant T cell survival and activation

31 March 2020

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Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection

31 March 2020

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PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice

31 March 2020

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The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action

31 March 2020

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c-Myb regulates the proliferation of immature thymocytes following beta-selection

31 March 2020

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c-Myc mediates pre-TCR-induced proliferation but not developmental progression

31 March 2020

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Pim kinase-dependent inhibition of c-Myc degradation

31 March 2020

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Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity

31 March 2020

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Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

31 March 2020

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Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

31 March 2020

1 reference

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

31 March 2020

1 reference

The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

31 March 2020

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

31 March 2020

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Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.

31 March 2020

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PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

31 March 2020

1 reference

Pim kinase substrate identification and specificity.

31 March 2020

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

31 March 2020

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

31 March 2020

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

31 March 2020

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

31 March 2020

1 reference

The survival kinases Akt and Pim as potential pharmacological targets

31 March 2020

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Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

31 March 2020

1 reference

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

31 March 2020

1 reference

A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma

31 March 2020

1 reference

Microarray-based classification of diffuse large B-cell lymphoma

31 March 2020

1 reference

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

31 March 2020

1 reference

Delineation of prognostic biomarkers in prostate cancer

31 March 2020

1 reference

Multiplex Biomarker Approach for Determining Risk of Prostate-Specific Antigen-Defined Recurrence of Prostate Cancer

31 March 2020

1 reference

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

31 March 2020

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Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas

31 March 2020

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Molecular diagnosis of Burkitt's lymphoma

31 March 2020

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Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation

31 March 2020

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

31 March 2020

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

31 March 2020

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Primary cutaneous marginal zone B-cell lymphomas are targeted by aberrant somatic hypermutation

31 March 2020

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Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma

31 March 2020

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MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation.

31 March 2020

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Aberrant somatic hypermutation in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma

31 March 2020

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

31 March 2020

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The great MYC escape in tumorigenesis

31 March 2020

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31 March 2020

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Genomic targets of the human c-Myc protein

31 March 2020

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Control of inducible gene expression by signal-dependent transcriptional elongation

31 March 2020

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c-Myc regulates transcriptional pause release

31 March 2020

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PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

31 March 2020

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14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation

31 March 2020

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Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation

31 March 2020

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PIM1 and MYC: a changing relationship?

31 March 2020

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Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

31 March 2020

1 reference

Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival

31 March 2020

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Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

31 March 2020

1 reference

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

31 March 2020

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mTORC1 promotes survival through translational control of Mcl-1.

31 March 2020

1 reference

Altering chemosensitivity by modulating translation elongation

31 March 2020

1 reference

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

31 March 2020

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Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

31 March 2020

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Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas

31 March 2020

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Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase

31 March 2020

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Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver

31 March 2020

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Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells

31 March 2020

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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

31 March 2020

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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

31 March 2020

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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

31 March 2020

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The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

31 March 2020

1 reference

BAD: undertaker by night, candyman by day.

31 March 2020

1 reference

Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

31 March 2020

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

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Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

31 March 2020

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

31 March 2020

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S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling

31 March 2020

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

31 March 2020

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

1 reference

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

31 March 2020

1 reference

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

31 March 2020

1 reference

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

31 March 2020

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

31 March 2020

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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

31 March 2020

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Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.

31 March 2020

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Adipocytes impair leukemia treatment in mice

31 March 2020

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Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

31 March 2020

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The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.

31 March 2020

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Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

31 March 2020

1 reference

Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma

31 March 2020

1 reference

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

31 March 2020

1 reference

Ruthenium half-sandwich complexes bound to protein kinase Pim-1

31 March 2020

1 reference

Pim kinase inhibitors: a survey of the patent literature

31 March 2020

1 reference

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

31 March 2020

1 reference

Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases

31 March 2020

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Myc-driven murine prostate cancer shares molecular features with human prostate tumors

31 March 2020

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Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

31 March 2020

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High-throughput insertional mutagenesis screens in mice to identify oncogenic networks

31 March 2020

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Regulation of RNA polymerase II elongation by c-Myc

31 March 2020

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Defining mechanisms that regulate RNA polymerase II transcription in vivo

31 March 2020

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Poised polymerases: on your mark...get set...go!

31 March 2020

1 reference

Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

31 March 2020

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

31 March 2020

1 reference

Classification of lymphoid neoplasms: the microscope as a tool for disease discovery

31 March 2020

1 reference

Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma

31 March 2020

1 reference

Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV.

31 March 2020

1 reference

Investigatory and analytical approaches to differential gene expression profiling in mantle cell lymphoma.

31 March 2020

1 reference

Primary mediastinal large B-cell lymphoma

31 March 2020

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Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer

31 March 2020

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Overexpression of PIM-1 is a potential biomarker in prostate carcinoma

31 March 2020

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Overexpression of Pim-1 during progression of prostatic adenocarcinoma

31 March 2020

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Growth and survival mechanisms associated with perineural invasion in prostate cancer

31 March 2020

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Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer

31 March 2020

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Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression

31 March 2020

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Gene expression profile predicts patient survival of gastric cancer after surgical resection

31 March 2020

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Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma.

31 March 2020

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Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

31 March 2020

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Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell

31 March 2020

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The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation

31 March 2020

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Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas

31 March 2020

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12 December 2020

IL-4 selectively inhibits IL-2-triggered Stat5 activation, but not proliferation, in human T cells

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12 December 2020

Overexpression of Pim-1 in head and neck squamous cell carcinomas.

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12 December 2020

Recombinant human pim-1 protein exhibits serine/threonine kinase activity

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12 December 2020

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma.

1 reference

12 December 2020

Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells

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12 December 2020

The human PIM-1 gene product is a protein serine kinase

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12 December 2020

Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer

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12 December 2020

The human pim-1 gene is not directly activated by the translocation (6;9) in acute nonlymphocytic leukemia

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12 December 2020

Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells

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12 December 2020

Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases

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12 December 2020

Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor

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12 December 2020

Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein

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12 December 2020

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

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12 December 2020

Pim-1 protein expression is regulated by its 5'-untranslated region and translation initiation factor elF-4E.

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12 December 2020

Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation

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12 December 2020

Pim-1 phosphorylates the DNA binding domain of c-Myb.

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12 December 2020

Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

1 reference

12 December 2020

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

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12 December 2020

Identifiers

DOI

10.1038/NRC2986

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23 August 2017

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