(Q33494281)

English

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

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scholarly article

1 reference

Europe PubMed Central

27 July 2017

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration (English)

1 reference

Europe PubMed Central

27 July 2017

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Stefan Knapp

14

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author name string

Rebekka Grundler

1

1 reference

Europe PubMed Central

27 July 2017

Laurent Brault

2

1 reference

Europe PubMed Central

27 July 2017

Christelle Gasser

3

1 reference

Europe PubMed Central

27 July 2017

Alex N Bullock

4

1 reference

Europe PubMed Central

27 July 2017

Tobias Dechow

5

1 reference

Europe PubMed Central

27 July 2017

Sabine Woetzel

6

1 reference

Europe PubMed Central

27 July 2017

Vanda Pogacic

7

1 reference

Europe PubMed Central

27 July 2017

Antonello Villa

8

1 reference

Europe PubMed Central

27 July 2017

Sabine Ehret

9

1 reference

Europe PubMed Central

27 July 2017

Georgina Berridge

10

1 reference

Europe PubMed Central

27 July 2017

Anke Spoo

11

1 reference

Europe PubMed Central

27 July 2017

Christine Dierks

12

1 reference

Europe PubMed Central

27 July 2017

Andrea Biondi

13

1 reference

Europe PubMed Central

27 July 2017

Justus Duyster

15

1 reference

Europe PubMed Central

27 July 2017

Juerg Schwaller

16

1 reference

Europe PubMed Central

27 July 2017

language of work or name

0 references

publication date

17 August 2009

1 reference

Europe PubMed Central

27 July 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

27 July 2017

206

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Europe PubMed Central

27 July 2017

9

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Europe PubMed Central

27 July 2017

1957-1970

1 reference

Europe PubMed Central

27 July 2017

Cancer stem cells: implications for the progression and treatment of metastatic disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Regulation of CXCR4 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Constitutively activated FLT3 phosphorylates BAD partially through pim-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Targeting the kinase activity of the BCR-ABL fusion protein in patients with chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Structure and substrate specificity of the Pim-1 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

How do stem cells find their way home?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

SDF-1 and CXCR4 in normal and malignant hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Resistance of Philadelphia-chromosome positive leukemia towards the kinase inhibitor imatinib (STI571, Glivec): a targeted oncoprotein strikes back

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Chemokines integrate JAK/STAT and G‐protein pathways during chemotaxis and calcium flux responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Chemokine receptor trafficking and viral replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

pim-1 proto-oncogene expression in anti-CD3-mediated T cell activation is associated with protein kinase C activation and is independent of Raf-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

21 June 2018

Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

CXCR4 is a prognostic marker in acute myelogenous leukemia.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20082074

21 January 2018

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737164

31 October 2018

CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19687226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19687226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

1 reference

https://pubmed.ncbi.nlm.nih.gov/19687226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20082074

1 reference

Europe PubMed Central

27 July 2017

1 reference

Europe PubMed Central

27 July 2017

1 reference

Europe PubMed Central

27 July 2017

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