(Q24295043)

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Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

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Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis (English)

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apoptotic process

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BCL2 associated agonist of cell death

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GOA release 2020-03-11

Pim-3 proto-oncogene, serine/threonine kinase

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GOA release 2020-03-11

protein kinase binding

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GOA release 2020-03-11

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based on heuristic

inferred from title

Naofumi Mukaida

object named as

Naofumi Mukaida

7

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author name string

Boryana Konstantinova Popivanova

1

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Ying-Yi Li

2

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Huachuan Zheng

3

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Kenji Omura

4

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Chifumi Fujii

5

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Koichi Tsuneyama

6

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language of work or name

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publication date

March 2007

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98

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321-8

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3

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KID-1, a protein kinase induced by depolarization in brain

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Prevention of protein denaturation under heat stress by the chaperonin Hsp60

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2007.00390.X

20 April 2017

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

20 April 2017

Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Pim family kinases enhance tumor growth of prostate cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Apoptosis and APC in colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

The survival kinases Akt and Pim as potential pharmacological targets

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Genome-wide differences between microsatellite stable and unstable colorectal tumors.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Inactivating mutations of proapoptotic Bad gene in human colon cancers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

21 January 2018

Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2007.00390.X

7 January 2021

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