(Q35079596)

6 August 2017

title

Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly (English)

1 reference

6 August 2017

0 references

1 reference

Massimiliano Aceti

1

0 references

Courtney A Miller

9

object named as

Courtney A Miller

1 reference

6 August 2017

Thomas K Creson

2

1 reference

6 August 2017

Thomas Vaissiere

3

1 reference

6 August 2017

Camilo Rojas

4

1 reference

6 August 2017

Wen-Chin Huang

5

1 reference

6 August 2017

Ya-Xian Wang

6

1 reference

6 August 2017

Ronald S Petralia

7

1 reference

6 August 2017

Damon T Page

8

1 reference

6 August 2017

Gavin Rumbaugh

10

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6 August 2017

language of work or name

English

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publication date

13 August 2014

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6 August 2017

published in

Biological Psychiatry

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6 August 2017

volume

77

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6 August 2017

issue

9

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6 August 2017

page(s)

805-815

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Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

One gene, many neuropsychiatric disorders: lessons from Mendelian diseases.

8 July 2018

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Prioritization of neurodevelopmental disease genes by discovery of new mutations

8 July 2018

1 reference

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A polygenic burden of rare disruptive mutations in schizophrenia

8 July 2018

1 reference

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De novo mutations in schizophrenia implicate synaptic networks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

CNVs conferring risk of autism or schizophrenia affect cognition in controls

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Differential innervation of direct- and indirect-pathway striatal projection neurons.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

De Novo Gene Disruptions in Children on the Autistic Spectrum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

mTOR signaling in growth control and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Patterns and rates of exonic de novo mutations in autism spectrum disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Molecular and synaptic defects in intellectual disability syndromes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Extraordinary neoteny of synaptic spines in the human prefrontal cortex.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Dendritic spine pathology in neuropsychiatric disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Delayed stabilization of dendritic spines in fragile X mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Functional impact of global rare copy number variation in autism spectrum disorders

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Dendritic spine dynamics.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Diagnostic exome sequencing in persons with severe intellectual disability

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

De novo SYNGAP1 mutations in nonsyndromic intellectual disability and autism.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

SynGAP regulates steady-state and activity-dependent phosphorylation of cofilin.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326604

A novel de novo microdeletion spanning the SYNGAP1 gene on the short arm of chromosome 6 associated with mental retardation

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25444158

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

6p21.3 microdeletion involving the SYNGAP1 gene in a patient with intellectual disability, seizures, and severe speech impairment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25444158

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BIOPSYCH.2014.08.001

1 reference

6 August 2017

1 reference

6 August 2017

1 reference