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DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
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Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
title
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
author
Yi Zhang
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
author name string
Anh Tram Nguyen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
Olena Taranova
series ordinal
2
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stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
Jin He
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
language of work or name
English
0 references
publication date
26 April 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
number of pages
11
1 reference
based on heuristic
inferred from page(s)
published in
Blood
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
volume
117
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
issue
25
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
page(s)
6912-6922
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
cites work
DOT1L regulates dystrophin expression and is critical for cardiac function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Early mammalian erythropoiesis requires the Dot1L methyltransferase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Misguided transcriptional elongation causes mixed lineage leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
HOXA9 is required for survival in human MLL-rearranged acute leukemias
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
MLL translocations, histone modifications and leukaemia stem-cell development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Hox genes in hematopoiesis and leukemogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Chromatin modifications and their function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Restoration of p53 function leads to tumour regression in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The diverse functions of histone lysine methylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
hDOT1L links histone methylation to leukemogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
MLL: a histone methyltransferase disrupted in leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
MLL fusion partners AF4 and AF9 interact at subnuclear foci
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Dot1p modulates silencing in yeast by methylation of the nucleosome core
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
Growth suppression by p16ink4 requires functional retinoblastoma protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
8 July 2018
ES cell cycle progression and differentiation require the action of the histone methyltransferase Dot1L.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128482
retrieved
27 September 2018
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21521783
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21521783
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interaction of MLL amino terminal sequences with menin is required for transformation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21521783
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1182/BLOOD-2011-02-334359
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
PMC publication ID
3128482
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
PubMed publication ID
21521783
1 reference
stated in
Europe PubMed Central
PMC publication ID
3128482
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21521783%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 January 2020
ResearchGate publication ID
51078608
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