(Q35084782)

6 August 2017

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title

Role of integrins in cell invasion and migration (English)

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6 August 2017

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John D Hood

1

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6 August 2017

David A Cheresh

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 February 2002

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6 August 2017

published in

Nature Reviews Cancer

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6 August 2017

volume

2

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6 August 2017

issue

2

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6 August 2017

page(s)

91-100

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Cell spreading and lamellipodial extension rate is regulated by membrane tension

6 August 2017

cites work

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Kinetic model for integrin-mediated adhesion release during cell migration.

31 March 2020

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Function and interactions of integrins

31 March 2020

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Cell adhesion molecules, signal transduction and cell growth

31 March 2020

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Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics

31 March 2020

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Role of integrins in cancer: survey of expression patterns

31 March 2020

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Requirement of vascular integrin alpha v beta 3 for angiogenesis

31 March 2020

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Involvement of integrin alpha V gene expression in human melanoma tumorigenicity

31 March 2020

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Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

31 March 2020

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Changes in integrin and E-cadherin expression in neoplastic versus normal thyroid tissue

31 March 2020

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The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures

31 March 2020

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Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells

31 March 2020

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Changes in integrin receptors on oncogenically transformed cells.

31 March 2020

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Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin

31 March 2020

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Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand

31 March 2020

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Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration

31 March 2020

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Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

31 March 2020

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Biology and biochemistry of proteinases in tumor invasion.

31 March 2020

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Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)

31 March 2020

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Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase

31 March 2020

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Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

31 March 2020

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Signaling through focal adhesion kinase

31 March 2020

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Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase

31 March 2020

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Control of adhesion-dependent cell survival by focal adhesion kinase

31 March 2020

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FAK integrates growth-factor and integrin signals to promote cell migration

31 March 2020

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Expression of focal adhesion kinase gene and invasive cancer

31 March 2020

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

31 March 2020

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Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

31 March 2020

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Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation

31 March 2020

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Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

31 March 2020

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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

31 March 2020

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Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

31 March 2020

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CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

31 March 2020

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Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway

31 March 2020

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Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells

31 March 2020

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Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes

31 March 2020

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The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

31 March 2020

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A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth

31 March 2020

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

31 March 2020

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Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

31 March 2020

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Bifurcation of cell migratory and proliferative signaling by the adaptor protein Shc.

31 March 2020

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Cell migration--movin' on.

31 March 2020

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

31 March 2020

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Activation of Rac and Cdc42 by integrins mediates cell spreading

31 March 2020

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

31 March 2020

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Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers

31 March 2020

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Syndecan-4 Deficiency Impairs Focal Adhesion Formation Only under Restricted Conditions

31 March 2020

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

31 March 2020

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31 March 2020

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

31 March 2020

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

31 March 2020

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Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase

31 March 2020

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

31 March 2020

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

31 March 2020

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A role for p21-activated kinase in endothelial cell migration.

31 March 2020

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Integrins and GTPases in tumour cell growth, motility and invasion

31 March 2020

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Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

31 March 2020

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Growth factor activation of MAP kinase requires cell adhesion.

31 March 2020

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Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected].

31 March 2020

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Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

31 March 2020

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Regulation of cell motility by mitogen-activated protein kinase

31 March 2020

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Relative distribution of actin, myosin I, and myosin II during the wound healing response of fibroblasts.

31 March 2020

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Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

31 March 2020

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Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc

31 March 2020

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Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation

31 March 2020

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Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins

31 March 2020

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Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins

31 March 2020

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PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

31 March 2020

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Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells

31 March 2020

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

31 March 2020

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Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion

31 March 2020

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Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase

31 March 2020

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Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin

31 March 2020

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Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

31 March 2020

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Where the outside meets the inside: integrins as activators and targets of signal transduction cascades

31 March 2020

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The structural basis of dynamic cell adhesion: heads, tails, and allostery

31 March 2020

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Biophysical methods for the determination of antibody-antigen affinities

31 March 2020

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Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin

31 March 2020

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Taking cell-matrix adhesions to the third dimension

31 March 2020

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Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho

31 March 2020

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Role of Rho in chemoattractant-activated leukocyte adhesion through integrins

31 March 2020

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RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

31 March 2020

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Signaling networks linking integrins and rho family GTPases.

31 March 2020

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Integrin activation by R-ras.

31 March 2020

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Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway

31 March 2020

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Social controls on cell survival and cell death

31 March 2020

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A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription

31 March 2020

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Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

31 March 2020

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The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.

31 March 2020

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Cleavage of focal adhesion kinase by caspases during apoptosis

31 March 2020

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31 March 2020

Integrins and anoikis

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Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

31 March 2020

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Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

31 March 2020

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Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins

31 March 2020

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Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

31 March 2020

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Asymmetric distribution of the chemotactic peptide receptor on polymorphonuclear leukocytes

31 March 2020

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Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated

31 March 2020

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Cell migration: a physically integrated molecular process

31 March 2020

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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

31 March 2020

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Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src

31 March 2020

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Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC727

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6 August 2017

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