(Q35090965)

6 August 2017

title

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies (English)

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6 August 2017

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Wolfgang Schaefer

1

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6 August 2017

Jörg T Regula

2

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6 August 2017

Monika Bähner

3

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6 August 2017

Jürgen Schanzer

4

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6 August 2017

Rebecca Croasdale

5

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6 August 2017

Harald Dürr

6

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6 August 2017

Christian Gassner

7

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6 August 2017

Guy Georges

8

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6 August 2017

Hubert Kettenberger

9

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6 August 2017

Sabine Imhof-Jung

10

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6 August 2017

Manfred Schwaiger

11

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6 August 2017

Kay G Stubenrauch

12

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6 August 2017

Claudio Sustmann

13

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6 August 2017

Markus Thomas

14

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6 August 2017

Werner Scheuer

15

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6 August 2017

Christian Klein

16

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6 August 2017

language of work or name

English

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publication date

20 June 2011

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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6 August 2017

volume

108

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6 August 2017

issue

27

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6 August 2017

page(s)

11187-11192

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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Chemical generation of bispecific antibodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Cancer therapy with bispecific antibodies: Clinical experience.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Strategies and challenges for the next generation of therapeutic antibodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Therapeutic antibodies for autoimmunity and inflammation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Tumor regression in cancer patients by very low doses of a T cell-engaging antibody

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

VEGF as a therapeutic target in cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Recombinant approaches to IgG-like bispecific antibodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

PROTEIN-PROTEIN INTERACTIONS AMONG L POLYPEPTIDE CHAINS OF BENCE-JONES PROTEINS AND HUMAN γ-GLOBULINS

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Fab-scFv fusion protein: an efficient approach to production of bispecific antibody fragments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Bispecific human IgG by design

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

An efficient route to human bispecific IgG.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Variable region domain exchange influences the functional properties of IgG.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Vascular endothelial growth factor is a secreted angiogenic mitogen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Antibody domain mutants demonstrate autonomy of the antigen binding site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

The mouse cornea micropocket angiogenesis assay

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Design and production of novel tetravalent bispecific antibodies

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131342

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1019002108

Hybrid hybridomas and their use in immunohistochemistry

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1019002108

'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

21 January 2018

1 reference

12 December 2020

A Preliminary Crystallographic Investigation of a Human l-Type Bence-Jones Protein

1 reference

12 December 2020

Bispecific monoclonal antibodies from hybrid hybridomas

1 reference

12 December 2020

Impact of molecular processing in the hinge region of therapeutic IgG4 antibodies on disposition profiles in cynomolgus monkeys

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1019002108

1 reference

6 August 2017

0 references

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6 August 2017

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