(Q35096114)

6 August 2017

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title

The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid beta-protein and cholesterol (English)

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6 August 2017

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Makoto Michikawa

1

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6 August 2017

publication date

1 February 2003

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6 August 2017

published in

Molecular Neurobiology

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6 August 2017

volume

27

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6 August 2017

issue

1

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6 August 2017

page(s)

1-12

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Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice

6 August 2017

cites work

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12 December 2020

Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice

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12 December 2020

Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity

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12 December 2020

Increasing age alters transbilayer fluidity and cholesterol asymmetry in synaptic plasma membranes of mice

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12 December 2020

Statins and the risk of dementia

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12 December 2020

A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release.

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4.

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12 December 2020

Lipid metabolism parameters in patients with Alzheimer's disease and their first degree relatives

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12 December 2020

Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles

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12 December 2020

Alzheimer's disease: the amyloid cascade hypothesis

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12 December 2020

Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade

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12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

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12 December 2020

Cell death or synaptic loss in Alzheimer disease

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12 December 2020

A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage

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12 December 2020

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

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12 December 2020

Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes

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12 December 2020

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (A beta 1-40), which may potentially inhibit the fibril formation

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12 December 2020

Control of synapse number by glia

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12 December 2020

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

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12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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12 December 2020

Cholesterol protects PC12 cells from beta-amyloid induced calcium disordering and cytotoxicity.

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12 December 2020

Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study

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12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

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12 December 2020

Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?

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12 December 2020

Dendritic changes in Alzheimer's disease and factors that may underlie these changes

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12 December 2020

Alzheimer's disease: a central role for amyloid

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12 December 2020

A detergent-insoluble membrane compartment contains A beta in vivo

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12 December 2020

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

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12 December 2020

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

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12 December 2020

CNS synaptogenesis promoted by glia-derived cholesterol

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12 December 2020

Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice

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12 December 2020

Functional rafts in cell membranes

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12 December 2020

Cholesterol-dependent modulation of tau phosphorylation in cultured neurons

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12 December 2020

Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Apolipoproteins in human cerebrospinal fluid

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12 December 2020

Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasis

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12 December 2020

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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12 December 2020

Essential role for cholesterol in synaptic plasticity and neuronal degeneration

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12 December 2020

Nascent astrocyte particles differ from lipoproteins in CSF.

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12 December 2020

Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties.

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12 December 2020

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

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12 December 2020

Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid

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12 December 2020

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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12 December 2020

Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).

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12 December 2020

Use of statins in CNS disorders

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12 December 2020

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae.

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12 December 2020

Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1-deficient cells.

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12 December 2020

Apolipoprotein E polymorphism and Alzheimer's disease.

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12 December 2020

Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides.

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12 December 2020

Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.

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12 December 2020

Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol

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12 December 2020

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

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12 December 2020

Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.

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12 December 2020

Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes?

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12 December 2020

Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons.

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12 December 2020

Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging

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12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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12 December 2020

Amyloid beta-peptide1-40 increases neuronal membrane fluidity: role of cholesterol and brain region.

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12 December 2020

Identifiers

DOI

10.1385/MN:27:1:1

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Dimensions Publication ID

6 August 2017

1012564543

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