(Q35096678)

6 August 2017

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title

The PKC gene module: molecular biosystematics to resolve its T cell functions (English)

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6 August 2017

Gottfried Baier

1

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6 August 2017

publication date

1 April 2003

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6 August 2017

published in

Immunological Reviews

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6 August 2017

volume

192

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6 August 2017

page(s)

64-79

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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

6 August 2017

cites work

1 reference

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Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes

21 January 2018

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Activation of protein kinase C triggers its ubiquitination and degradation

21 January 2018

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

21 January 2018

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Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

21 January 2018

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Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta

21 January 2018

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Selective modulation of protein kinase C-theta during T-cell activation

21 January 2018

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A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

21 January 2018

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Optic flow: A brain region devoted to optic flow analysis?

21 January 2018

1 reference

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Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells

21 January 2018

1 reference

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Membrane compartmentation is required for efficient T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation

21 January 2018

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

21 January 2018

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Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.

21 January 2018

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

T cell expressed PKCtheta demonstrates cell-type selective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development

21 January 2018

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation

21 January 2018

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Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase Ctheta: a new essential superstar on the T-cell stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

A requirement for CARMA1 in TCR-induced NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Role of the protein kinase C lambda/iota isoform in nuclear factor-kappaB activation by interleukin-1beta or tumor necrosis factor-alpha: cell type specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Cutting edge: protein kinase C beta expression is critical for export of Il-2 from T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Activation of IkappaB kinase beta by protein kinase C isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Integrins and inside-out signal transduction: converging signals from PKC and PIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Differential downstream functions of protein kinase Ceta and -theta in EL4 mouse thymoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Crucial importance of PKC-beta(I) in LFA-1-mediated locomotion of activated T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C and the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Membrane raft association of CD47 is necessary for actin polymerization and protein kinase C theta translocation in its synergistic activation of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Molecular analysis of the interactions between protein kinase C-epsilon and filamentous actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C-alpha is essential for Ramos-BL B cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Involvement of protein kinase C-beta and ceramide in tumor necrosis factor-alpha-induced but not Fas-induced apoptosis of human myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Molecular controls of antigen receptor clustering and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Doing immunology on a chip.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Partners in transcription: NFAT and AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Role of zeta PKC in B-cell signaling and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

T-cell signal transduction and the role of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Synergistic activation of NF-kappa B by functional cooperation between vav and PKCtheta in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Altered substrate selectivity of PKC-eta pseudosubstrate site mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

T cell antigen receptor dependent signalling in human lymphocytes: cholera toxin inhibits interleukin-2 receptor expression but not interleukin-2 synthesis by preventing activation of a protein kinase C isotype, PKC-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Inhibition of protein kinase C alpha expression by antisense RNA in transfected Jurkat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Analysis of the role of protein kinase C-alpha, -epsilon, and -zeta in T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Subcellular localization and translocation of protein kinase C isoforms zeta and epsilon in human peripheral blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Interleukin-11 induces rapid PKC activation and cytosolic to particulate translocation of alpha and beta PKC isoforms in human erythroleukemia K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Localization of protein kinases by anchoring proteins: a theme in signal transduction

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Protein kinase C isozymes and the regulation of diverse cell responses

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

The Actin Cytoskeleton and Lymphocyte Activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Protein kinase C and T cell activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

T cell activation induced by anti-CD3 antibodies requires prolonged stimulation of protein kinase C.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Binding of protein kinase C isoforms to actin in Aplysia

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Physical association and functional relationship between protein kinase Cζ and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Molecular genetics and structural genomics of the human protein kinase C gene module

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Immunodeficiency in protein kinase cbeta-deficient mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

Modified hippocampal long-term potentiation in PKCγ-mutant mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00018.X

7 January 2021

10.1034/J.1600-065X.2003.00018.X

Identifiers

DOI

1 reference

6 August 2017

1 reference