(Q35102319)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

5 February 2020

main subject

Toxoplasma gondii

0 references

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

14 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

18 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

19 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

20 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

20 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

20 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

20 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

20 December 2018

1 reference

4-hydroxy-3-methylbut-2-enyl diphosphate reductase

20 December 2018

0 references

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, putative

0 references

author

Christopher Goodman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Sandeep Sundriyal

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Boris Striepen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Geoffrey Ian McFadden

5

object named as

Geoffrey I McFadden

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Sethu C Nair

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Carrie F Brooks

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Angelika Sturm

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Justin L Anglin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Yongcheng Song

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Silvia N J Moreno

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

language of work or name

English

0 references

publication date

20 June 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

5 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

1547-1559

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

Glycerophospholipid acquisition in Plasmodium - a puzzling assembly of biosynthetic pathways

5 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Metabolic pathways in the apicoplast of apicomplexa.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Structural basis of substrate selectivity in the glycerol-3-phosphate: phosphate antiporter GlpT.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Theileria apicoplast as a target for chemotherapy

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Structure and non-essential function of glycerol kinase inPlasmodium falciparumblood stages

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Toxoplasma gondii Tic20 is essential for apicoplast protein import

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

The plastid-like organelle of apicomplexan parasites as drug target

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Expression and processing of Plasmodium berghei SERA3 during liver stages.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Salt-bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Anti-infectives targeting the isoprenoid pathway of Toxoplasma gondii

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Fosmidomycin, a novel chemotherapeutic agent for malaria

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Complementation of a Toxoplasma gondii ROP1 knock-out mutant using phleomycin selection.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135366

Babesia and plasmodia increase host erythrocyte permeability through distinct mechanisms

9 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

Mitochondrial tRNA import in Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

Natural immunization against malaria: causal prophylaxis with antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants ofEscherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

A nutrient-permeable channel on the intraerythrocytic malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20110039

Identification and characterisation of Toxoplasma gondii protein farnesyltransferase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21690250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isoprenoid biosynthesis in bacteria: two different pathways?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21690250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21690250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20110039

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21690250%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference