(Q35103205)

English

A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

0 references

protein C deficiency

1 reference

based on heuristic

inferred from title

Francis J Castellino

2

object named as

Francis J Castellino

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

Jorge G Ganopolsky

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

language of work or name

0 references

publication date

1 October 2004

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

The American Journal of Pathology

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

165

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

1433-1446

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Activated protein C signals through the thrombin receptor PAR1 in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

The enigma of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Interleukin-12 and -18 induce severe liver injury in mice recovered from peritonitis after sublethal endotoxin challenge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Novel strategies for the treatment of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

The epidemiology of sepsis in the United States from 1979 through 2000

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Aging and thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Molecular crosstalk between p70S6k and MAPK cell signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Hepatic response to sepsis: interaction between coagulation and inflammatory processes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Efficacy and safety of recombinant human activated protein C for severe sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Thrombin signalling and protease-activated receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

The value of animal models in the development of new drugs for the treatment of the sepsis syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Neurogenic inflammation in an animal model of neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Preparation and properties of bovine factor VIII (antihemophilic factor).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Sepsis and septic shock--a review of laboratory models and a proposal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Clinical relevance of protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Inducible endothelial functions in inflammation and coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Detection of circulating tumor necrosis factor after endotoxin administration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

The clinical spectrum of heterozygous protein C deficiency in a large New England kindred

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Mortality and bacteriology of sepsis following cecal ligation and puncture in aged mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Hereditary protein C deficiency: a review of the genetics, clinical presentation, diagnosis and treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Lipopolysaccharide-tumor necrosis factor-glucocorticoid interactions during cecal ligation and puncture-induced sepsis in mature versus senescent mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

9 July 2018

Effects of drotrecogin alfa (activated) in human endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

PAR1 signaling: more good than harm?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Genetic contribution to the septic response in a mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Low levels of protein C are associated with poor outcome in severe sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Endogenous MCP-1 influences systemic cytokine balance in a murine model of acute septic peritonitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Coagulation activation and tissue necrosis in meningococcal septic shock: severely reduced protein C levels predict a high mortality.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

27 September 2018

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618621

16 November 2018

Linkage between inflammation and coagulation: An update on the molecular basis of the crosstalk

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Disseminated intravascular coagulation

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Plasminogen activator inhibitor 2 and urokinase-type plasminogen activator in plasma and leucocytes in patients with severe sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Protein C levels in severe sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Whole blood clot lysis: in vitro modulation by activated protein C

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Expression and contribution of endogenous IL-13 in an experimental model of sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Antibiotic treatment influences outcome in murine sepsis: mediators of increased morbidity

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Genetic background determines susceptibility during murine septic peritonitis

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Thrombin triggers the de novo expression of an inducible NO synthase in porcine aortic valve endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats -- a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Plasma levels of soluble thrombomodulin increase in cases of disseminated intravascular coagulation with organ failure

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Tissue factor expression in vital organs during murine traumatic shock: role of transcription factors AP-1 and NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Blood coagulation equilibrium in rat liver microcirculation as evaluated by endothelial cell thrombomodulin and macrophage tissue factor

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

Role of tissue factor in ischemia-reperfusion injury: immunohistochemical assessment of tissue factor pathway inhibitor staining of the liver

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2963401-3

7 January 2021

A new function for activated protein C: activated protein C prevents inhibition of plasminogen activators by releasate from mononuclear leukocytes--platelet suspensions stimulated by phorbol diester

1 reference

https://pubmed.ncbi.nlm.nih.gov/15466407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Septicemia, portal thrombosis and congenital protein C deficiency]

1 reference

https://pubmed.ncbi.nlm.nih.gov/15466407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein C, protein S and C4b-binding protein in severe infection and septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/15466407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disseminated intravascular coagulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15466407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester

1 reference

https://pubmed.ncbi.nlm.nih.gov/15466407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15466407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease-activated receptors in vascular biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15466407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S0002-9440(10)63401-3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

release_n7f7lz5cd5bgpcdxkt3e7dn73m

1 reference

https://api.fatcat.wiki/v0/release/n7f7lz5cd5bgpcdxkt3e7dn73m

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35103205&oldid=1843778598"