(Q35112355)

24601604

6 August 2017

title

A high-throughput cell-based method to predict the unbound drug fraction in the brain (English)

1 reference

6 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Pär Matsson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Per Artursson

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

0 references

publication date

20 March 2014

1 reference

24601604

Journal of Medicinal Chemistry

6 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

57

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

3005-3010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

Rapid measurement of intracellular unbound drug concentrations.

9 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

BDDCS applied to over 900 drugs

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Assessing brain free fraction in early drug discovery

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu).

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Microdialysis in mice for drug delivery research

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

Species independence in brain tissue binding using brain homogenates

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985417

In vivo measurement of blood-brain barrier permeability

27 September 2018

1 reference

12 December 2020

QSAR analysis of blood-brain distribution: the influence of plasma and brain tissue binding

1 reference

12 December 2020

High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery

1 reference

12 December 2020

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM401963N

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

24601604

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24601604%20AND%20SRC:MED&resulttype=core&format=json