(Q82676939)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

1 reference

title

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Dennis A Smith

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Li Di

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Edward H Kerns

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

1 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

17 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

929-939

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd3287

17 January 2020

exact match

0 references

cites work

Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus

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Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor

31 March 2020

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Design of a potent, soluble glucokinase activator with excellent in vivo efficacy.

31 March 2020

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Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.

31 March 2020

1 reference

Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors

31 March 2020

1 reference

Changes in plasma protein binding have little clinical relevance

31 March 2020

1 reference

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

31 March 2020

1 reference

CSF as a surrogate for assessing CNS exposure: an industrial perspective

31 March 2020

1 reference

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.

31 March 2020

1 reference

On the rate and extent of drug delivery to the brain.

31 March 2020

1 reference

Determination of fluconazole concentrations in the prostatic and seminal vesicle fluid (split ejaculate).

31 March 2020

1 reference

Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses.

31 March 2020

1 reference

Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

31 March 2020

1 reference

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

31 March 2020

1 reference

Physicochemical profiling (solubility, permeability and charge state).

31 March 2020

1 reference

Strategies to assess blood-brain barrier penetration

31 March 2020

1 reference

Development of a computational approach to predict blood-brain barrier permeability

31 March 2020

1 reference

Clinical pharmacokinetics of cimetidine

31 March 2020

1 reference

Drug penetration in solid tumours

31 March 2020

1 reference

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

31 March 2020

1 reference

Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG.

31 March 2020

1 reference

Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog.

31 March 2020

1 reference

Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat.

31 March 2020

1 reference

Effects of fluoroquinolones on HERG currents

31 March 2020

1 reference

Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

31 March 2020

1 reference

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

31 March 2020

1 reference

Development of an improved IP(1) assay for the characterization of 5-HT(2C) receptor ligands

31 March 2020

1 reference

A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

31 March 2020

1 reference

Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach.

31 March 2020

1 reference

Clopidogrel: a review of its mechanism of action

31 March 2020

1 reference

A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties

31 March 2020

1 reference

An automated electrophysiology serum shift assay for K(V) channels

31 March 2020

1 reference

The importance of plasma protein binding in drug discovery

31 March 2020

1 reference

Weak Binding of VX-478 to Human Plasma Proteins and Implications for Anti-Human Immunodeficiency Virus Therapy

31 March 2020

1 reference

Relevance of plasma protein binding to antiviral activity and clinical efficacy of inhibitors of human immunodeficiency virus protease

31 March 2020

1 reference

Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines

31 March 2020

1 reference

Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis

31 March 2020

1 reference

High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery

31 March 2020

1 reference

Compound lipophilicity for substrate binding to human P450s in drug metabolism

31 March 2020

1 reference

Free drug fraction vs free drug concentration: a matter of frequent confusion

31 March 2020

1 reference

Impact of plasma-protein binding on receptor occupancy: an analytical description.

31 March 2020

1 reference

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists

31 March 2020

1 reference

Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists

31 March 2020

1 reference

Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase

31 March 2020

1 reference

Corticotropin-releasing factor receptor antagonists

31 March 2020

1 reference

KA-672 inhibits rat brain acetylcholinesterase in vitro but not in vivo.

31 March 2020

1 reference

Challenges for blood-brain barrier (BBB) screening

31 March 2020

1 reference

Quantitative pharmacology or pharmacokinetic pharmacodynamic integration should be a vital component in integrative pharmacology

31 March 2020

1 reference

On the mechanism of the persistent action of salmeterol: what is the current position?

31 March 2020

1 reference

Ligands, their receptors and ... plasma membranes

31 March 2020

1 reference

Inhibition of cardiac L-type calcium channels by quaternary amlodipine: implications for pharmacokinetics and access to dihydropyridine binding site.

31 March 2020

1 reference

Molecular mechanisms for the persistent bronchodilatory effect of the beta 2-adrenoceptor agonist salmeterol

31 March 2020

1 reference

Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor

31 March 2020

1 reference

P-glycoprotein related drug interactions: clinical importance and a consideration of disease states

31 March 2020

1 reference

Significance of protein binding in pharmacokinetics and pharmacodynamics

31 March 2020

1 reference

Physiologic models of hepatic drug clearance: influence of altered protein binding on the elimination of diclofenac in the isolated perfused rat liver

31 March 2020

1 reference

The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS.

31 March 2020

1 reference

Ceftriaxone binding to human serum albumin. Indirect displacement by probenecid and diazepam.

31 March 2020

1 reference

Displacement of disopyramide from human plasma proteins

31 March 2020

1 reference

Effect of diltiazem on warfarin plasma protein binding

31 March 2020

1 reference

The (ir)relevance of plasma protein binding of anticancer drugs

31 March 2020

1 reference

Plasma Protein Displacement Interactions Are Rarely of Clinical Significance

31 March 2020

1 reference

What is the true clinical significance of plasma protein binding displacement interactions?

31 March 2020

1 reference

Plasma protein binding displacement interactions--why are they still regarded as clinically important?

31 March 2020

1 reference

Protein binding drug displacement interactions fact or fiction?

31 March 2020

1 reference

Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia

31 March 2020

1 reference

Prediction of therapeutic doses of beta-adrenergic receptor blocking agents based on quantitative structure-pharmacokinetic/pharmacodynamic relationship

31 March 2020

1 reference

Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo

31 March 2020

1 reference

Clofibrate displaces warfarin from plasma proteins in man: an example of a pure displacement interaction

31 March 2020

1 reference

12 December 2020

Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations.

1 reference

12 December 2020

A new concept regarding the mechanism of action of omeprazole.

1 reference

12 December 2020

Pharmacokinetics and tissue penetration of fluconazole in humans

1 reference

12 December 2020

Towards a drug concentration effect relationship for QT prolongation and torsades de pointes

1 reference

12 December 2020

Strategies to optimize brain penetration in drug discovery.

1 reference

12 December 2020

Role of pharmacokinetics and metabolism in drug discovery and development

1 reference

12 December 2020

Fluconazole and other azoles: translation of in vitro activity to in vivo and clinical efficacy

1 reference

12 December 2020

Clinical significance of drug binding, protein binding, and binding displacement drug interactions.

1 reference

12 December 2020

The partitioning of cimetidine into canine cerebrospinal fluid

1 reference

12 December 2020

Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer

1 reference

12 December 2020

Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21119731%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference